肝脏常温机械灌注修复及评估系统的研制  

Development of Liver Normothermic Machine Perfusion Repair and Assessment System

作　　者：刘雯雁[1,2] 刘锋锋 吕毅[2] 汤博[2] 马涛 闫炀[3] 郑云巧 郑幸龙[2,3] LIU Wenyan;LIU Fengfeng;LYU Yi;TANG Bo;MA Tao;YAN Yang;ZHENG Yunqiao;ZHENGXinglong(Department of Blood Purification,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,710061;First Affiliated Hospital of Xi’an Jiaotong University,National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine,Xi’an,710061;Department of Cardiovascular Surgery,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,710061;Department of Operation and Anesthesia,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,710061)

机构地区：[1]西安交通大学第一附属医院血液净化科,西安市710061 [2]西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心,西安市710061 [3]西安交通大学第一附属医院心血管外科,西安市710061 [4]西安交通大学第一附属医院麻醉手术部,西安市710061

出　　处：《中国医疗器械杂志》2021年第1期37-41,共5页Chinese Journal of Medical Instrumentation

基　　金：国家自然科学基金(81800581);中央高校基本科研业务费专项资金(xjj2018276);陕西省自然科学基础研究基金(2019JQ-952)。

摘　　要：介绍了一种肝脏常温机械灌注修复及评估系统。系统由肝脏常温氧合机械灌注装置、荧光成像系统及组织测氧仪组成。常温氧合机械灌注装置可对供肝进行持续灌注并实时监测调控灌注参数,荧光成像系统通过识别肝脏代谢的吲哚菁绿来评估供肝微循环情况及肝细胞代谢功能,组织测氧仪可实时监测肝组织氧分压变化评估细胞耗氧状态。This paper introduced a liver normothermic machine perfusion repair and assessment system.This system consists of a liver normothermic machine perfusion device,a fluorescence imaging system and a tissue oxygen detector.The normothermic machine perfusion device can continuously perfuse the donor liver and monitor and control the perfusion parameters in real time.The fluorescence imaging system can detect the indocyanine green metabolized by the liver to evaluate the microcirculation and the metabolism function of hepatocytes.The tissue oxygen detector can monitor the change of oxygen partial pressure of liver tissue in real time to evaluate the state of cell oxygen consumption.

关 键 词：常温机械灌注 供肝保存 供肝评估 

分 类 号：R197.39[医药卫生—卫生事业管理] R318[医药卫生—公共卫生与预防医学]