阿奇霉素联合甲泼尼龙琥珀酸钠治疗小儿重症支原体肺炎的临床评价  

Clinical Evaluation of Azithromycin combined with Methylprednisolone Sodium Succinate in the Treatment of Mycoplasma Pneumonia in Children

作　　者：李晓慧 杨波 LI Xiao-hui;YANG Bo(Department of Pediatrics,Lingyuan Central Hospital,Lingyuan 122500,China)

机构地区：[1]凌源市中心医院儿科,辽宁凌源122500

出　　处：《中国医药指南》2020年第35期45-46,共2页Guide of China Medicine

摘　　要：目的探究阿奇霉素与甲泼尼龙琥珀酸钠联合用药方案在小儿重症支原体肺炎患儿中的应用效果及安全性。方法选取本院2017年1月至2019年1月接诊的90例重症支原体肺炎小儿患儿开展观察,按照随机双盲法,将患儿均分成对照组(n=45)和试验组(n=45)。对照组采用阿奇霉素治疗,试验组采用阿奇霉素联合甲泼尼龙琥珀酸钠治疗,回顾性分析比较两组的临床疗效、不良反应和炎性因子水平。结果试验组患儿的临床治疗总有效率、治疗后CRP水平明显优于对照组(P<0.05);两组患儿不良反应发生率比较无差异(P>0.05)。结论对于患有重症支原体肺炎的患儿,同时给予甲泼尼龙琥珀酸钠与阿奇霉素治疗有利于患儿病情恢复,促进炎性因子吸收,且安全性较高。Objective To explore the effect and safety of azithromycin combined with methylprednisolone sodium succinate in children with severe mycoplasma pneumonia.Methods We selected 90 children with severe mycoplasma pneumonia admitted in our hospital from January 2017 to January 2019 for observation.According to the random double-blind method,the children were divided into a control group(n=45)and a test group(n=45).The control group was treated with azithromycin,and the test group was treated with azithromycin combined with methylprednisolone sodium succinate.The clinical efficacy,adverse reactions and inflammatory factor levels of the two groups were retrospectively analyzed and compared.Results The total effective rate of clinical treatment and the level of CRP after treatment in the experimental group were significantly better than those in the control group(P<0.05);there was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For children suffering from severe mycoplasma pneumonia,simultaneous treatment of methylprednisolone sodium succinate and azithromycin is beneficial to the recovery of the children's condition,promotes the absorption of inflammatory factors,and was safer.

关 键 词：小儿重症支原体肺炎 阿奇霉素 甲泼尼龙琥珀酸钠 临床疗效 安全性 

分 类 号：R563.1[医药卫生—呼吸系统] R725.6[医药卫生—内科学]