甲亢131碘治疗后早发甲减患者的临床治疗  

Clinical Analysis of Early Hypothyroidism after 131 Iodine Treatment for Hyperthyroidism

作　　者：郑俊敏 ZHENG Junmin(Department of Endocrinology,Sanming First Hospital,Fujian Medical University,Sanming 365000,China)

机构地区：[1]福建医科大学附属三明第一医院内分泌科,福建三明365000

出　　处：《中国医药指南》2020年第35期89-90,共2页Guide of China Medicine

摘　　要：目的探讨分析甲亢131碘治疗后早发甲减患者的临床治疗方法及其预后转归情况。方法选取我院2017年4月至2018年6月治疗的68例因甲亢进行131碘治疗后早期发生甲减的患者作为研究对象,分为观察组(规范化用药治疗)和对照组(常规用药指导)各34例。观察两组患者的临床预后。结果与对照组相比,观察组患者的治疗有效率(94.12%>73.53%,χ2=5.314)、生活质量量表(SF-36)评分[(78.26±4.51)分>(70.85±4.83)分,t=6.538]以及治疗后的FT3水平[(4.14±0.67)pmol/L>(3.56±0.53)pmol/L,t=3.959]、FT4水平[(11.75±1.53)pmol/L>(8.96±0.95)pmol/L,t=9.033]相对更高(P<0.05),而焦虑自评量表(SAS)评分[(36.91±3.74)分<(51.25±4.09)分,t=15.087]、治疗后的TSH水平[(3.82±0.69)mIU/L<(5.13±0.72)mIU/L,t=7.660]相对更低(P<0.05)。结论在甲亢131碘治疗后早发甲减患者的临床治疗期间,采取规范化用药治疗,合理使用治疗药物,可改善其甲状腺功能,有效改善患者的预后。Objective To investigate and analyze the clinical treatment and prognosis of hyperthyroidism patients with early hypothyroidism after 131 iodine treatment.Methods Sixty-eight patients with early hypothyroidism due to hyperthyroidism after 131 iodine treatment in our hospital from April 2017 to June 2018 were selected as the research objects and divided into the observation group(standardized drug treatment)and the control group(conventional drug guidance)with 34 cases in each group,and the clinical prognosis of the two groups was observed.Results Compared with the control group,the effective rate(94.12%>73.53%,χ2=5.314),SF-36 score[(78.26±4.51)>(70.85±4.83),t=6.538],FT3 level[(4.14±0.67)pmol/L>(3.56±0.53)pmol/L,t=3.959]and FT4 level[(11.75±1.53)pmol/L>(8.96±0.95)pmol/L,t=9.033]in the observation group were significantly higher than those in the control group,the scores of SAS[(36.91±3.74)points<(51.25±4.09)points,t=15.087]and TSH[(3.82±0.69)mIU/L<(5.13±0.72)mIU/L,t=7.660]were lower after treatment(P<0.05).Conclusion During the clinical treatment of patients with early-onset hypothyroidism after 131 iodine treatment for hyperthyroidism,standardized medication and rational use of therapeutic drugs can improve their thyroid function and effectively improve the prognosis of patients.

关 键 词：甲状腺功能亢进症 131碘治疗 甲状腺功能减退症 临床预后 

分 类 号：R581.1[医药卫生—内分泌] R581.2[医药卫生—内科学]