左氧氟沙星联合抗结核化疗方对复治涂阳肺结核患者的疗效  

Effect of Levofloxacin Combined with Anti-tuberculosis Chemotherapy on Retreated Smear-positive Pulmonary Tuberculosis

作　　者：李红涛 LI Hongtao(Department of Respiratory,Fuxin Infectious Diseases Hospital,Fuxin 123000,China)

机构地区：[1]阜新市传染病医院呼吸科,辽宁阜新123000

出　　处：《中国医药指南》2020年第35期123-124,共2页Guide of China Medicine

摘　　要：目的探讨左氧氟沙星联合抗结核化疗方对复治涂阳肺结核患者的治疗效果。方法采用回顾性分析法,选取本科室84例复治涂阳肺结核患者,时间为2018年3月至2019年3月,按随机抽签法将患者分为两组,各42例。对照组采用抗结核化疗方案进行治疗,观察组采用左氧氟沙星联合抗结核化疗方案进行治疗。对比两组患者治疗效果、痰菌转阴率和不良反应发生情况。结果治疗总有效率对比,试验组为92.86%,高于对照组的71.43%(χ2=9.015,P<0.05);试验组治疗2、4、6个月后痰菌转阴率分别为88.09%、95.24%、97.62%,均高于对照组的71.43%、73.81%、80.95%(χ2=8.315、9.612、3.057,P<0.05);不良反应对比,观察组为4.76%,低于对照组的14.29%(χ2=5.125,P<0.05)。结论在复治涂阳肺结核患者治疗中,左氧氟沙星与抗结核化疗方案联合应用,不仅可促进患者痰菌转阴率提高,而且有助于降低不良反应的发生率,使患者早日康复。Objective To investigate the therapeutic effect of levofloxacin combined with anti-tuberculosis chemotherapy on retreated smearpositive pulmonary tuberculosis.Methods Using retrospective analysis,we selected 84 patients with smear-positive pulmonary tuberculosis who were retreated in the undergraduate room from March 2018 to March 2019.The patients were divided into two groups according to a random lottery method,each with 42 cases.The control group was treated with anti-tuberculosis chemotherapy,and the observation group was treated with levofloxacin combined with anti-tuberculosis chemotherapy.The treatment effect,sputum conversion rate and the occurrence of adverse reactions were compared between the two groups.Results Compared with the total effective rate of treatment,the test group was 92.86%,which was higher than 71.43%of the control group(χ2=9.015,P<0.05);the negative rate of sputum bacteria in the test group after 2,4,and 6 months of treatment was 88.09%,95.24%and 97.62%,both higher than 71.43%,73.81%,80.95%of the control group(χ2=8.315,9.612,3.057,P<0.05);adverse reaction comparison,the observation group was 4.76%,lower than the control group 14.29%(χ2=5.125,P<0.05).Conclusion In the treatment of smear-positive pulmonary tuberculosis patients,the combined application of levofloxacin and anti-tuberculosis chemotherapy can not only promote the increase of the negative rate of sputum bacteria in patients,but also help reduce the incidence of adverse reactions and enable patients to recover quickly.

关 键 词：复治涂阳肺结核 左氧氟沙星 抗结核药物 化疗 痰菌转阴率 

分 类 号：R521[医药卫生—内科学]