儿童反复呼吸道感染与血清维生素A、E的相关性及危险因素  

The association of recurrent respiratory infections in children with serum vitamin A and E levels as well as risk factors

作　　者：李昊威 史颖 卢冠男[2] LI Haowei;SHI Ying;LU Guannan(Department of Pediatrics,Yingkou Hospital of Traditional Chinese Medicine,Yingkou 115000,Liaoning,China;Department of Respiratory Medicine,the Affiliated Hospital of Jilin Medical College,Jilin 132013,Jilin,China)

机构地区：[1]辽宁省营口市中医院儿科,辽宁营口115000 [2]吉林医药学院附属医院呼吸内科,吉林吉林132013

出　　处：《贵州医科大学学报》2021年第1期91-94,104,共5页Journal of Guizhou Medical University

基　　金：国家卫生计生委医药卫生科技发展研究中心项目(W2015EAE119);吉林省高等教育学会(JGJX2018D155)。

摘　　要：目的 探讨儿童反复呼吸道感染(RRI)与血清维生素A、E水平的相关性及相关危险因素。方法108例RRI儿童作为观察组,100例同期健康儿童作为对照组,于入院当日、或体检时采集受试者空腹静脉血,采用高效液相色谱法检测血清维生素A和E水平;收集2组受试儿童体质量指数(BMI)、年龄、性别、出生体质量、早产儿、喂养史、过敏体质、鼻炎/鼻窦炎、平均每日户外运活动时间(> 30 min)、家庭经济状况、父母文化程度及维生素A、E指标,采用Spearman法分析儿童RRI与血清维生素A、E水平的相关性,采用二元Logistic回归分析影响儿童RRI的相关危险因素。结果 观察组患儿维生素A和E水平低于对照组儿童,差异有统计学意义(P<0.05);观察组维生素A和E水平不足患儿比例高于对照组儿童,差异有统计学意义(P<0.05);Spearman法结果显示,儿童RRI与血清维生素A、E水平呈现负相关性(r=-0.475、-0.388,P<0.001),维生素A和E存在正相关性(r=0.389,P<0.001);Logistic回归分析显示,低BMI、早产儿、维A缺乏及过敏体质是儿童RRI的危险因素(OR=4.232、2.321、3.873、1.675及6.457),而户外活动时间是儿童RRI的保护因素(OR=0.454)。结论 儿童RRI与血清维生素A、E水平关系密切,低BMI、早产儿、维A缺乏、过敏体质以及户外活动时间是儿童RRI的影响因素。Objective To investigate the association of recurrent respiratory infections(RRI) in children with serum vitamin A and E levels as well as related risk factors.Methods One hundred and eight RRI children were taken as observation group,and 100 healthy children at the same period were recruited as control group.On the day of admission or physical examination,fasting venous blood was collected from these children,and the serum vitamin A and E levels were detected by high performance liquid chromatography.Additionally, body mass index(BMI), age, gender, birth weight,premature infant, feeding history, allergic constitution, rhinitis/sinusitis, average daily outdoor exercise time(> 30 min),family economic status,parents’ education levels,the levels of serum vitamin A and E were collected.Spearman correlation analyses were conducted to analyze the association of RRI with serum vitamin A and E.Binary Logistic regression was used to analyze risk factors relevant to RRI.Results The vitamin A and E levels were lower in observation group than those in control group(P<0.05).The proportion of children with insufficient vitamin A and E levels was greater in observation group than that in control group(P<0.05).Spearman correlation analyses showed that RRI was negatively correlated with serum vitamin A and E levels(r =-0.475,-0.388,P < 0.001).Vitamin A and E were positively correlated(r=0.389,P < 0.001).Moreover,Logistic regression analysis showed that low BMI,premature infants,vitamin A deficiency,and allergies were risk factors for children’s RRI(OR=4.232,2.321,3.873,1.675,and 6.457,respectively).In contrast,outdoor activity was a protective factor for children ’s RRI(OR=0.454).Conclusion Children’s RRI is closely related to serum vitamin A and E levels.Low BMI,premature infants,vitamin A deficiency,allergies,and outdoor activities are the factors influencing children’s RRI.

关 键 词：维生素A 维生素E 儿童 反复呼吸道感染 影响因素 

分 类 号：R725[医药卫生—儿科]