Risk factors for Blastocystis infection in HIV/AIDS patients with highly active antiretroviral therapy in Southwest China  

作　　者：Shun-Xian Zhang Fen-yan Kang Jia-Xu Chen Li-Guang Tian Lan-Lan Geng 

机构地区：[1]Guangzhou Institute of Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,People's Republic of China [2]Department of Gastroenterology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,People's Republic of China [3]The Gansu Center for Disease Control and Prevention,Lanzhou 730000 People's Republic of China [4]National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Shanghai 200025,People's Republic of China [5]Key Laboratory for Parasitology and Vector Biology,MOH of China,WHO Collaborating Center for Topical Diseases,National Center for International Research on Tropical Diseases,Shanghai 20025,People's Republic of China

出　　处：《Infectious Diseases of Poverty》2019年第5期83-90,共8页贫困所致传染病（英文）

基　　金：The data analysis of this study was supported by China Postdoctoral Science Foundation Grant(No.2018 M64303043);the postdoctoral research funding from Guangzhou Women and Children's Medical Center(No.5001-3001075);the field epidemiological investigation and Blastocystis detection were supported by the National Natural Science Foundation of China(No.81473022);in addition,and the English edit was supported by the 13th Five-Year National Science and Technology Major Project for Infectious Diseases(No.2017ZX1030550-002).

摘　　要：Background:Blastocystis is a widespread zoonotic protozoan of mammalian species,especially in HIV/AIDS individuals.The aim of this study was to analyze the prevalence and risk factors related with Blastocystis infection among HIV/AIDS patients in Southwest China.Methods:The cross-sectional study was performed in 311 HIV/AIDS cases in Tengchong City,Yunnan Province from July 2016 to March 2017.For each subject,stool specimen was collected to detect the Blastocystis,and the blood sample was used to detect HIV virus load and CD4+T cell count,in addition,structured questionnaire was used to collect the basic information and risk factors.Findings:The result showed that the detection rate of Blastocystis was 3.86%(95%CI:2.22-6.62)among HIV/AIDS patients.Both raising animal(OR=12.93,95%CI:1,54-108.36)and drinking un-boiled water(OR=8A7,95%CI:1.76-37.90)were risk factors for Blastocystis infection in HIV/AIDS individuals.In addition,the interaction of CD4^+T cell count and HIV virus load was also contribution to Blastocystis infection(P=0.007).Conclusions:A high prevalence of Blastocystis infection was found in HIV/AIDS patients in Tengchong.Poor hygienic habits,the interaction of HIV virus load and CD4^+T cell count were identified as main risk factors for infection.These results will help us to develop efficient control strategies to intervene with and prevent the occurrence of Blastocystis among HIV-infected individuals.

关 键 词：BLASTOCYSTIS HIV/AIDS CO-INFECTION Risk factor Interaction 

分 类 号：R51[医药卫生—内科学]