血小板输注次数及输血小板前预防性用药对输血反应发生率的影响  

Influence of platelet transfusion times and preventive medication before platelet transfusion on the incidence of blood transfusion reactions

作　　者：沈佳坤 董慧娟 郑林 李春艳 颜静秀 SHEN Jia-kun;DONG Hui-juan;ZHENG Lin;LI Chun-yan;YAN Jing-xiu(Department of Hematology,Shangrao People′s Hospital,Jiangxi Province,Shangrao334000,China)

机构地区：[1]江西省上饶市人民医院血液科,江西上饶334000

出　　处：《中国当代医药》2021年第2期22-25,共4页China Modern Medicine

摘　　要：目的研究血小板输注次数及输血小板前预防性用药对输血反应发生率的影响。方法通过调查2017年2月~2018年8月上饶市人民医院血液科170例患者血小板输注后输血反应的发生情况,根据同一例患者的输血小板次数分为M1组(<5次)、M2组(5~9次)、M3组(≥10次),根据有无输血反应史分为有输血反应史组和无输血反应史组,分析不同输血次数及预防性用药对输血反应发生率的影响。结果170例需要输注血小板的血液病患者进行了784例次血小板输注,共发生输血反应61次,输血反应发生率为7.8%。M1组、M2组、M3组三组患者的输血反应发生率比较,差异有统计学意义(P<0.05)。M1、M2和M3三组各组内有预防性用药情况下和无预防性用药情况下的输血反应发生率比较,差异均无统计学意义(P>0.05)。无输血反应史组与有输血反应史组的输血反应发生率比较,差异有统计学意义(P<0.05)。无论是有输血反应史组还是无输血反应史组,有预防性用药情况下的输血反应发生率与无预防性用药情况比较,差异无统计学意义(P>0.05)。结论输血次数越多,出现输血不良反应的患者越多。有输血反应史的患者输血反应发生率高于无输血反应史者。预防性用药对多次输血者及有输血反应史者的输血反应发生率均无影响。Objective To study the influence of platelet transfusion times and preventive medication before platelet transfusion on the incidence of blood transfusion reactions.Methods The incidence of blood transfusion reactions after platelet transfusion in 170 patients in the Department of Hematology,Shangrao People′s Hospital from February 2017 to August 2018 was investigated,they were divided into M1 group(<5 times),M2 group(5-9 times)and M3 group(≥10 times)according to the number of platelet transfusions of the same patient,according to the history of transfusion reactions,they were divided into group with history of transfusion reactions and group without history of transfusion reactions,the influence of different blood transfusion times and preventive medication on the incidence of blood transfusion reactions was analyzed.Results A total of 784 cases of platelet transfusions were performed in 170 patients with hematologic diseases requiring platelet transfusion,there were 61 transfusion reactions,the incidence of transfusion reactions was 7.8%.There was statistically significant difference in the incidence of transfusion reactions among patients in the M1,M2,and M3 groups(P<0.05).There was no statistically significant difference in the incidence of blood transfusion reactions in the three groups of M1,M2 and M3 with and without preventive medication(P>0.05).There was statistically significant difference in the incidence of transfusion reactions between the group without history of transfusion reactions and the group with history of transfusion reactions(P<0.05).There was no statistically significant difference in the incidence of blood transfusion reaction in the case of preventive medication and no preventive medication in the group with or without history of transfusion reactions(P>0.05).Conclusion The more times of blood transfusion,the more patients with adverse reactions of blood transfusion.The incidence of blood transfusion reactions in patients with history of blood transfusion reaction is higher than tha

关 键 词：机采血小板 输血不良反应 预防性用药 

分 类 号：R457.1[医药卫生—治疗学]