可溶性B7⁃H4对系统性红斑狼疮和疾病活动的诊断价值  

Soluble B7⁃H4 expression and diagnostic value in the patients with systemic lupus erythematosus and dis⁃ease activity

作　　者：俞大亮[1] 傅艳平[1] 李浪 陈飞[1] 李六生[1] 李玉斌[1] YU Daliang;FU Yanping;LI Lang;CHEN Fei;LI Liusheng;LI Yubin(Department of Nephrolo-gy,Three Gorges University People′s Hospital,the First People′s Hospital of Yichang,Yichang 443000,China)

机构地区：[1]三峡大学人民医院,宜昌市第一人民医院肾内科,湖北宜昌443000

出　　处：《实用医学杂志》2021年第2期260-263,共4页The Journal of Practical Medicine

基　　金：宜昌市医疗卫生研究项目(编号:A20⁃2⁃031)。

摘　　要：目的分析可溶性B7⁃H4在系统性红斑狼疮(systemic lupus erythematosus,SLE)患者以及疾病活动中的诊断价值。方法收集60例SLE患者和健康体检者20例,SLEDAI评分评估SLE的疾病活动性,ELISA法检测SLE患者和健康体检者血清中可溶性B7⁃H4(soluble B7⁃H4,sB7⁃H4)的含量。结果(1)SLE患者sB7⁃H4含量[(65.62±21.02)ng/mL]明显高于正常对照组[(55.4±11.2)ng/mL],差异有统计学意义(P<0.05);sB7⁃H4诊断SLE的敏感性为56%,特异性85%,ROC曲线下面积为0.65。(2)SLE患者疾病活动组sB7⁃H4含量[(70.99±19.85)ng/mL]明显高于稳定组[(59.06±20.89)ng/mL],差异有统计学意义(P<0.05);在SLE患者中sB7⁃H4诊断活动期SLE的敏感性为82%,特异性为56%,ROC曲线下面积为0.687。结论sB7⁃H4有助于SLE的诊断,且对SLE疾病活动的预测有重要价值。Objective To investigate the diagnostic value of soluble B7⁃H4 in the patients with SLE.Methods 60 SLE patients and 20 healthy donors were recruited.Disease activity was assessed by SLEDAI scores.The sB7⁃H4 of serum in SLE and healthy donors were analysed using ELISA,and the correlation between sB7⁃H4 of serum in SLE and disease active parameters was analysed too.Results The sB7⁃H4 in serum of SLE patients[(65.62±21.02)ng/mL]was significantly higher than healthy controls[(55.4±11.2)ng/mL](P<0.05).The sensitivity and specificity of sB7⁃H4 to diagnose active SLE in the SLE group were 56%and 85%respectively,and the area under ROC curve was 0.65.The mean concentration of sB7⁃H4 level in active disease group[(70.99±19.85)ng/mL]were significantly higher than those in inactive disease group[(59.06±20.89)ng/mL](P<0.05),the sensitivity and specificity of sB7⁃H4 to diagnose active disease in the SLE group were 82%and 56%respectively,the area under ROC curve was 0.687.Conclusion The expression of sB7⁃H4 probably may contribute to the diag⁃nosis and reflect the disease activity of SLE.

关 键 词：可溶性B7⁃H4 系统性红斑狼疮 诊断 

分 类 号：R593.241[医药卫生—内科学]