急性冠脉综合征患者PCI后心律失常与血清miR-1、miR-17-5p表达的相关性分析  

Correlation analysis between arrhythmia after PCI and expressions of miR-1, miR-17-5p in serum inpatients with acute coronary syndrome

作　　者：万艳波 刘明[1] 贾银明[2] 王勇[1] 张正伟[1] 王素利 Wan Yanbo;Liu Ming;Jia Yinming;Wang Yong;Zhang Zhengwei;Wang Suli(Department of cardiovascular medicine,The People's Hospital of Anyang City,Henan 455000,China;不详)

机构地区：[1]安阳市人民医院心血管内科,安阳455000 [2]安阳市中医院中西结合心血管病诊疗中心,安阳455001 [3]安阳地区医院神经外科,安阳455000

出　　处：《中国循证心血管医学杂志》2020年第12期1526-1529,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的检测急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)后血清中微小RNA(miR)-1、miR-17-5p表达水平及与心律失常的关系。方法选取2018年3月至2019年4月于安阳市人民医院173例ACS患者为研究对象,所有患者均行PCI,根据Lown分级标准分心律正常组(110例)和心律失常组(63例)。收集2组患者一般资料;实时荧光定量PCR(qRT-PCR)检测血清中miR-1、miR-17-5p水平;分析ACS心律失常患者Lown分级与血清中miR-1、miR-17-5p关系;受试者工作特性曲线(ROC)分析血清中miR-1、miR-17-5p水平对ACS患者心律失常的诊断价值;Logistic分析影响ACS患者心律失常的因素。结果与心律正常组相比,心律失常组患者吸烟史、心肌梗死(心梗)史、心功能分级、左室射血分数(LVEF)均值存在显著差异(P<0.05),血清中miR-1、miR-17-5p水平升高(P<0.05)。ACS心律失常患者随着Lown分级的升高,血清中miR-1、miR-17-5p水平逐渐升高(P<0.05)。ROC曲线显示,血清中miR-1、miR-17-5p预测ACS患者发生心律失常的曲线下面积分别为0.778、0.821,截断值为1.54、1.52,对应的灵敏度为61.9%、71.4%,特异度为91.8%、90.0%;二者联合预测ACS患者发生心律失常的曲线下面积为0.925,灵敏度77.8%、特异性94.5%。Logistic结果显示,心梗史、心功能分级、miR-1、miR-17-5p是影响ACS患者心律失常的独立危险因素(P<0.05),LVEF是影响ACS患者心律失常的保护因素(P<0.05)。结论ACS患者PCI后心律失常患者血清中miR-1、miR-17-5p水平升高,与Lown分级关系密切,对ACS患者PCI后心律失常有一定诊断价值。Objective To detect the expression levels of microRNA(miR-1)and miR-17-5p in the serum of acute coronary syndrome(ACS)patients after percutaneous coronary intervention(PCI)and its relationship with arrhythmia.Methods 173 ACS patients in Anyang People's Hospital from March 2018 to April 2019 were selected as the study objects,and all patients were treated with PCI.According to the Lown grading standard,they were divided into 110 patients in the normal cardioversion group and 63 patients in the arrhythmia group.The general data of the two groups were collected;the levels of miR-1 and miR-17-5p in serum were detected by real-time fluorescent quantitative PCR(qRT-PCR);the relationships between Lown grading and serum miR-1,miR-17-5p in patients with ACS arrhythmia were analyzed;the diagnostic values of serum miR-1 and miR-17-5p levels in patients with ACS were analyzed by receiver operating characteristic curve(ROC);and Logistic analysis was used to analyze the influencing factors of arrhythmia in ACS patients.Results Compared with the normal rhythm group,there were significant differences in smoking history,myocardial infarction history,cardiac function grading and LVEF mean value in the arrhythmia group(P<0.05),and the levels of miR-1 and miR-17-5p in serum increased(P<0.05).With the increase of Lown grading,the levels of serum miR-1 and miR-17-5p in patients with ACS arrhythmia increased gradually(P<0.05).ROC curve showed that the areas under the curve of miR-1 and miR-17-5p in serum to predict the occurrence of arrhythmia in ACS patients were 0.778 and 0.821 respectively,the cutoff values were 1.54 and 1.52,the corresponding sensitivities were 61.9%and 71.4%,and the specificities were 91.8%and 90.0%;the area under the curve of the combination predicting arrhythmia in ACS patients was 0.925,the sensitivity was 77.8%,and the specificity was 94.5%.The results of Logistic analysis showed that the history of myocardial infarction,the classification of cardiac function,miR-1 and miR-17-5p were independent risk factors o

关 键 词：急性冠脉综合征 经皮冠状动脉介入 心律失常 微小RNA-1 微小RNA-17-5p 

分 类 号：R541.4[医药卫生—心血管疾病]