血管型白塞病的发病机制  

Pathogenesis of vasculo-Behcet's disease

作　　者：王之冕 李璐 郑文洁 WANG Zhi-mian;LI Lu;ZHENG Wen-jie(Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Key Laboratory of Rheumatology&Clinical Immunology,Ministry of Education,National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID),Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,风湿免疫病学教育部重点实验室,国家皮肤与免疫疾病临床医学研究中心,北京100730

出　　处：《中华临床免疫和变态反应杂志》2020年第6期587-591,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家自然科学基金(81871299)。

摘　　要：白塞病(Behet's disease,BD)是一种病因及发病机制尚不明确的慢性全身性血管炎性疾病,其中有血管受累的被称为血管型BD(Vasculo-Behet's disease)。本文从中性粒细胞活化、内皮细胞损伤、凝血功能障碍3个方面描述血管型BD发病机制,为临床治疗和疾病管理提供参考。Behcet’s disease( BD) is a chronic systemic vasculitis of unknown etiology and pathogenesis.The involvement of the vascular system,which dominates the clinical picture in Behcet’s disease,is termed vasculo-Behcet’s disease. This article aims to describe the pathogenesis of vasculo-BD from three aspects including neutrophil activation,endothelial dysfunction,and coagulation disorders,so as to provide references for clinical treatment and disease management.

关 键 词：白塞病 血管炎 中性粒细胞活化 内皮损伤 凝血障碍 

分 类 号：R59[医药卫生—内科学]