慢性肾脏病与肠道菌群相关性研究进展概述  

Summary of research advances on the correlation between chronic kidney disease and gastrointestinal microbiome

作　　者：陈丽华 张美玲 钟鸿斌 黄继义[1] Chen Li-hua;Zhang Mei-ling;Zhong Hong-bin;Huang Ji-yi(Department of Nephrology,Xiang'an District of the First Affiliated Hospital of Xiamen University,Xiamen 361101,China;Division of Clinical Medicine,Fujian Medical University,Fuzhou 350122,China)

机构地区：[1]厦门大学附属第一医院翔安院区肾内科,361101 [2]福建医科大学临床医学部,福州350122

出　　处：《临床肾脏病杂志》2021年第1期74-78,共5页Journal Of Clinical Nephrology

摘　　要：中国慢性肾脏病(chronic kidney disease,CKD)发病率高,呈逐年增长趋势,目前尚无根治手段,积极探索CKD进展的危险因素是目前肾脏病领域的研究重点。近年越来越多学者指出,肠道菌群变化与CKD发生发展存在一定相关性,肠道微生态平衡对人体健康有着举足轻重的作用,而CKD患者肠道黏膜受损后可引起肠道菌群紊乱,继发肠源性毒素堆积,加重CKD进展;本文就目前国内外有关CKD与肠道菌群研究进行概述,进一步探讨以调节肠道菌群紊乱作为CKD防治新靶点的可能性。The incidence of chronic kidney disease(CKD)in China has remained elevated and it shows an annually rising trend.However,no radical cure is not currently available.Exploring the risk factors of CKD is a research focus of nephrology.It is generally accepted that the change of intestinal flora was correlated with the development of CKD.And micro-ecological balance of gut might impact upon human health.However,owing to an impairment of intestinal function barrier and an alteration of intestinal flora,an accumulation of gut derived toxin gradually induced a continuous deterioration of CKD.This review was intended to describe the relativity between CKD and intestinal flora and explore the possibility of modulating intestinal flora as a new therapeutic target for CKD.

关 键 词：慢性肾脏病 肠道菌群 益生菌 

分 类 号：R692[医药卫生—泌尿科学]