稳定期双相情感障碍Ⅰ型患者注意及执行功能与血清同型半胱氨酸水平相关性研究  

Research on the correlation between attention and executive function and serum homocysteine level in patients with typeⅠbipolar affective disorder in stationary phase

作　　者：苏伟[1] 钱敏才[1] 孙菊水[1] 吴丽娜[1] 李建华[1] 薛亮 那万秋[1] SU Wei;QIAN Mincai;SUN Jushui;WU Li'na;LI Jianhua;XUE Liang;NA Wanqiu(Department of Psychiatry,Huzhou Third People's Hospital in Zhejiang Province,Huzhou 313000,China)

机构地区：[1]浙江省湖州市第三人民医院精神科,浙江湖州313000

出　　处：《中国现代医生》2020年第35期72-75,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2018KY785);浙江省湖州市科技计划项目(2016GY36)。

摘　　要：目的探讨稳定期双相情感障碍Ⅰ型患者注意及执行功能与血清同型半胱氨酸水平的相关性。方法选取2017年1月~2018年6月在湖州市第三人民医院就诊的稳定期双相情感障碍Ⅰ型患者80例(研究组)和健康志愿者60例(对照组),采用连线测验A(TMTA)评定其注意功能,采用连线测验B(TMTB)、Stroop色词测验(SCT、SCWT)评定其执行功能;同时检测两组血清同型半胱氨酸(Hcy)水平。对两组结果进行比较及相关性分析。结果TMT、SCT、SCWT各量表评分显示,研究组注意及执行功能均低于对照组,差异有统计学意义(P<0.05);研究组血清Hcy水平为(18.85±6.12)μmol/L,高于对照组的(11.06±3.32)μmol/L,差异有统计学意义(P<0.001)。研究组TMTA、TMTB、TMT干扰量、SCTS、SCWTS与血清Hcy值均呈正相关(r=0.432、0.608、0.489、0.872、0.742,P<0.05);研究组SCT、SCWT与血清Hcy值均呈负相关(r=-0.703、-0.764,P<0.001)。TMT、SCT、SCWT各量表评分与年龄、受教育时间、病程均无相关性(P>0.05)。结论稳定期双相情感障碍Ⅰ型患者存在注意及执行功能损害,并且血清Hcy水平增高,其注意及执行功能损害与血清Hcy水平增高相关。Objective To investigate the correlation between attention and executive function and serum homocysteine level in patients with typeⅠbipolar affective disorder in stationary phase.Methods Patients with typeⅠbipolar affective disorder in stationary phase selected as the study group(n=80)and healthy volunteers selected as the control group(n=60)from January 2017 to June 2018 in Huzhou Third People's Hospital were adopted to evaluate their attention function by using the trail making test A(TMTA),and their executive function by using the trail making test B(TMTB)and Stroop color word test(SCT,SCWT).Synchronously,the serum homocysteine(Hcy)levels of the two groups were detected.The results of the two groups were compared and the correlations were analyzed.Results The scale scores of TMT,SCT and SCWT show that the attention and executive function in the study group were all lower than those in the control group,the difference was statistically significant(P<0.05),and the serum Hcy level in the study group(18.85±6.12)μmol/L was higher than that of the control group(11.06±3.32)μmol/L,the difference was statistically significant(P<0.001).In the study group,TMTA,TMTB,TMT interference value,SCTS and SCWTS were positively correlated with serum Hcy value(r=0.432,0.608,0.489,0.872,0.742,P<0.05),while the accurate value of SCT and SCWT were negatively correlated with serum Hcy value(r=-0.703,-0.764,P<0.001).There was no correlation with age,education time and course of disease in the scale scores of TMT,SCT and SCWT(P>0.05).Conclusion Patients with typeⅠbipolar affective disorder in stationary phase have impaired attention function and executive function,and increased serum Hcy level.The impairment of attention function and executive function is related to the increase of serum Hcy level.

关 键 词：执行功能 注意功能 同型半胱氨酸 双相情感障碍 稳定期 

分 类 号：R749.4[医药卫生—神经病学与精神病学]