周围神经损伤修复过程以及miRNA在周围神经修复中的研究进展  

The repair process of peripheral nerve injury and the research progress of miRNA in peripheral nerve repair

作　　者：蒋玲丽 魏在荣 Jiang Lingli;Wei Zairong(Department of Burn Plastic Surgery,the Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou,563099,China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科,贵州遵义563099

出　　处：《遵义医科大学学报》2020年第6期801-806,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81560315);贵州省创面外科整合治疗科技创新人才团队[NO:黔科合平台人才[2020]5012];贵州省社发公关项目[NO:黔科合支撑([2017]2877)]。

摘　　要：周围神经损伤(Peripheral nerve injuries,PNI)是临床常见的创伤之一,在我国发病率较高,但目前治疗方案仍然存在局限性。PNI修复是一个复杂的过程,主要经历了华勒变性、修复雪旺细胞以及“神经桥”形成等过程。在神经修复过程中,miRNA起到十分关键的调控作用,针对调控通路中的关键因素开发新型药物,对提高PNI治疗效果及改善患者的生存质量有重要意义。Peripheral nerve injuries(PNI)is a common clinical disease with a high incidence in China,but there are still many limitations in the current treatment.PNI repair mainly goes through the processes of Wallerian degeneration,Schwann cell repair,and"nerve bridge"formation.miRNA plays a key role in the PNI repair process.The development of new drugs aiming at the key factors in the regulation pathway is of great significance for improving the cure rate of PNI and improving the quality of life of patients.

关 键 词：周围神经损伤 修复 华勒变性 雪旺细胞 MIRNA 外泌体 

分 类 号：R722.14[医药卫生—儿科]