上海市COVID-19患者康复前后淋巴细胞绝对数分析  

Analysis on the absolute value of lymphocyte in COVID-19 patients before and after recovery in Shanghai

作　　者：樊剑 郭颖 戚伟强[1] 郜梦露 张腾飞 朱召芹[1] FAN Jian;GUO Ying;QI Weiqiang;HAO Menglu;ZHANG Tengfei;ZHU Zhaoqin(Shanghai Public Health Clinical Center,Shanghai 201508,China)

机构地区：[1]上海市公共卫生临床中心,上海201508

出　　处：《检验医学》2021年第1期44-47,共4页Laboratory Medicine

基　　金：上海市科学技术委员会应急攻关项目(20411950502);上海市公共卫生临床中心院内专项课题(2020YJKY01);国家“十三五”科技部重大专项项目(2018ZX10714002-001-005)。

摘　　要：目的评估淋巴细胞绝对数(LYMPH#)检测在新型冠状病毒肺炎(COVID-19)患者临床预后判断中的价值。方法选取123例严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染患者作为研究对象,其中轻型及普通型112例(轻型及普通型组),重型及危重型11例(重型及危重型组)。回顾性收集所有患者外周血LYMPH#的初诊检测结果、出院前检测结果和初次随访检测结果;收集所有患者的临床资料。结果重症患者的年龄比轻症患者大。轻型及普通型组50.89%(57/112)的患者LYMPH#初诊检测结果低于正常值,重型及危重型组72.73%(8/11)的患者LYMPH#初诊检测结果低于正常值。轻型及普通型组和重型及危重型组LYMPH#初诊检测结果比较,无显著性差异(P=0.789)。轻型及普通型组和重型及危重型组之间LYMPH#恢复数值[(初次随访检测结果–初诊检测结果)/初次随访检测结果]和LYMPH#差值(初次随访检测结果–出院前检测结果)均有显著性差异(P=0.014和P=0.038)。结论SARS-CoV-2感染患者的细胞免疫功能普遍低下,康复出院的重症患者免疫功能需要进行持续监测,LYMPH#可作为临床监测COVID-19患者免疫功能和评估预后的指标。Objective To evaluate the role of absolute lymphocyte count(LYMPH#)in predicting prognosis of corona virus disease 2019(COVID-19)patients.Methods A total of 123 COVID-19 patients were enrolled in this retrospective study.There were 112 mild cases and 11 severe cases.The LYMPH#in peripheral blood were collected at the initial hospitalization,before discharge,and at the initial follow-up.Clinical data of all the patients were also collected.Results Severe patients were older than mild patients.At the initial hospitalization,the LYMPH#of 50.89%(57/112)of mild group was lower than normal value,and the LYMPH#of 72.73%(8/11)of severe group was lower than referencevalue.There was no significant difference in the LYMPH#between mild group and severe group at the initial hospitalization(P=0.789).There was significant difference in the recovery LYMPH#[(initial follow-up results–first admission results)/initial follow-up results]between the two groups(P=0.014).There was the difference of LYMPH#between before discharge and the first follow-up(P=0.038).Conclusion The cellular immune function of COVID-19 patients is generally low,and needs continuous monitoring.LYMPH#can be used as an indicator to monitor the immune function and predict the prognosis of COVID-19 patients.

关 键 词：新型冠状病毒肺炎 淋巴细胞绝对数 预后 

分 类 号：R446.1[医药卫生—诊断学]