肌骨超声在痛风性关节炎急性发作期的应用价值及与血液指标的相关性  

Application value of musculoskeletal ultrasound in acute attack of gouty arthritis and its correlation with blood index

作　　者：胡洋扬[1] 李咏梅[1] 常景建 HU Yangyang;LI Yongmei;CHANG Jingjian(Department of Ultrasound,the Third People's Hospital of Yancheng City,Yancheng 224001,China)

机构地区：[1]江苏省盐城市第三人民医院超声科,224001

出　　处：《安徽医学》2020年第12期1415-1419,共5页Anhui Medical Journal

摘　　要：目的探讨肌骨超声在痛风性关节炎急性发作期的应用价值及与血液指标的相关性。方法选择2019年1~12月江苏省盐城市第三人民医院健康体检的50例老年人群作为健康对照组,以本院同期收治的107例痛风性关节炎老年人群作为病例观察组,根据临床症状及病史问询结果,病例观察组分为急性发作组(44例)与稳定期组(63例)。所有患者均行关节肌骨超声检查和病情相关血液指标检查,分析肌骨超声评分与病情相关血液指标的相关性。结果健康对照组、稳定期组、急性发作组患者的肌骨超声综合评分差异有统计学意义(P<0.05)。肌骨超声综合评分鉴别诊断痛风性关节炎的的曲线下面积(AUC)为0.885,准确度、敏感度、特异度分别为71.44%、77.25%和73.61%(P<0.001),肌骨超声综合评分的鉴别阈值为4.38分。肌骨超声综合评分鉴别诊断痛风性关节炎稳定期与急性发作期的的AUC为0.861,准确度、敏感度、特异度分别为70.81%、76.36%和71.49%(P<0.001),肌骨超声综合评分的鉴别阈值为8.89分。急性发作痛风性关节炎患者肌骨超声综合评分与5-羟色胺、P物质和超敏C-反应蛋白、白细胞介素-6及肿瘤坏死因子-α均呈正相关(P<0.05)。结论肌骨超声综合评分与病情相关血液指标具有相关性,肌骨超声在鉴别痛风性关节炎急性发作和稳定期鉴别中具有一定的临床价值。Objective To explore the application value of musculoskeletal ultrasound in acute attack stage of gouty arthritis and its correlation with blood index.Methods From January to December 2019,50 elderly patients who received a physical examination at the Third People’s Hospital of Yancheng City,Jiangsu Province were selected as the healthy control group,and 107 elderly patients with gouty arthritis admitted to this hospital during the same period were selected as the observation group.The case observation group was divided into acute attack group(44 cases)and stable stage group(63 cases)according to clinical symptoms and history inquiry results.All patients underwent joint musculoskeletal ultrasound examination and disease-related blood index examination,and the correlation between musculoskeletal ultrasound score and disease-related blood index was analyzed.Results There were statistically significant differences in the comprehensive musculoskeletal ultrasound scores of the healthy control group,stable group and acute attack group(P<0.05).The AUC for the differential diagnosis of gouty arthritis was 0.885,and the accuracy,sensitivity,and specificity was 71.44%,77.25%,and 73.61%(P<0.001),respectively,with a differential threshold of 4.38 points for the comprehensive score of musculoskeletal ultrasound.The AUC for the differential diagnosis of stable gouty arthritis versus acute exacerbation was 0.861,and the accuracy,sensitivity,and specificity was 70.81%,76.36%,and 71.49%(P<0.001),respectively,with a differential threshold of 8.89 points for the comprehensive score of musculoskeletal ultrasound.The musculoskeletal ultrasound imaging score was 8.89 points.The comprehensive score of musculoskeletal ultrasound of patients with acute onset gouty arthritis was positively correlated with 5-HT,SP,IL-6,TNF-α,and hs-CRP(P<0.05).Conclusions The comprehensive score of musculoskeletal ultrasound is correlated with blood indicators related to the disease.Musculoskeletal ultrasound has certain clinical value in distinguishing

关 键 词：肌骨超声 痛风性关节炎 急性发作 应用价值 血液指标 

分 类 号：R589.7[医药卫生—内分泌]