大麻二酚抗肿瘤作用及其机制研究进展  

Antitumor effects of cannabidiol and its molecular mechanism:research advances

作　　者：王欣 于京[1] WANG Xin;YU Jing(Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in Universities of Gansu Province,Northwest University for Nationalities,Lanzhou 730000,China)

机构地区：[1]西北民族大学环境友好复合材料及生物质利用甘肃省高校重点实验室,兰州730000

出　　处：《国际药学研究杂志》2020年第12期1057-1061,1077,共6页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(21865028);中央高校基本科研业务费专项资助项目(31920190080)。

摘　　要：大麻二酚是植物大麻中的主要成分之一,对多种疾病具有治疗效果,如炎症、多发性硬化、神经退行性病、癫痫等。已有研究表明,大麻二酚可在对正常细胞几乎无影响的前提下,通过多种作用机制抑制肿瘤细胞增殖、转移、侵袭,并诱导细胞凋亡,具有抗肿瘤药物的开发潜质。本文就大麻二酚在不同类型肿瘤中的作用及可能的分子机制进行综述,为大麻二酚抗肿瘤活性的进一步研究提供参考。Cannabidiol(CBD)is one of the main components in plant cannabis and has therapeutic effects on a variety of dis⁃eases,such as inflammation,multiple sclerosis,neurodegenerative diseases and epilepsy.Research results have shown that CBD could inhibit tumor cell proliferation,metastasis and invasion and induce apoptosis via a variety of mechanisms with almost no effect on normal cells,which thus has the therapeutic potential as antitumor drugs.This review mainly focuses on the antitumor effect and possible molecular mechanisms of CBD,so as to provide reference for the future work on the more related biological activities of CBD.

关 键 词：大麻二酚 抗肿瘤 作用机制 

分 类 号：R96[医药卫生—药理学]