藤黄酸纳米给药系统在肿瘤治疗中的作用研究进展  

Research progress in gambogic acid nanoparticle drug delivery system in tumor therapy

作　　者：李哲 申应涛 武继彪 刘珊[3] 冯玉[1] 孙鹏[1,2] LI Zhe;SHEN Ying-tao;WU Ji-biao;LIU Shan;FENG Yu;SUN Peng(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Key Laboratory of TCM Classical Theory,Ministry of Education,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Experimental Center.Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,济南250355 [2]山东中医药大学中医药经典理论教育部重点实验室,济南250355 [3]山东中医药大学实验中心,济南250355

出　　处：《国际药学研究杂志》2020年第12期1062-1068,共7页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81874419);国家“重大新药创制”科技重大专项资助项目(2017ZX09301064)。

摘　　要：藤黄酸是中药藤黄的主要活性成分,因其对多种恶性肿瘤细胞有良好的抑制作用而成为重要的抗癌候选药物。但藤黄酸具有溶解性差、半衰期短和生物利用度低等缺点,限制了其在肿瘤治疗中的应用。藤黄酸纳米给药系统因能克服藤黄酸的上述缺点,而逐渐被开发并应用于肿瘤治疗。本文对近年报道的藤黄酸纳米给药系统的抗肿瘤作用进行综述,以期为藤黄酸的成药性研究提供依据。Gambogic acid,the main active component of traditional Chinese medicine gamboge,has become an important anticancer drug candidate because of its good inhibitory effect on a variety of malignant tumor cells.However,gambogic acid has some disadvantages,such as poor solubility,short half-life and low bioavailability,which limits its application in tumor therapy.Gambogic acid nanoparticle delivery system has been gradually developed and used in tumor therapy because it can overcome the above shortcom⁃ings of gambogic acid.This paper reviews the anti-tumor effect of gambogic acid nanoparticle delivery system reported in recent years,in order to provide a basis for the study of the medicinal properties of gambogic acid.

关 键 词：藤黄酸 纳米给药系统 抗肿瘤 

分 类 号：R94[医药卫生—药剂学] R96[医药卫生—药学]