110例胆道感染患者胆汁细菌培养与抗菌药物应用情况分析  

Analysis of Bile Bacterial Culture and Application of Antibiotics in 110 Patients with Biliary Tract Infection

作　　者：朱燕霞 聂增新 张小斌 ZHU Yanxia;NIE Zengxin;ZHANG Xiaobin(Jingdezhen First People's Hospital,Jingdezhen Jiangxi 333000,China)

机构地区：[1]景德镇市第一人民医院,江西景德镇333000

出　　处：《药品评价》2020年第23期46-48,共3页Drug Evaluation

摘　　要：目的:分析胆道感染患者胆汁细菌培养与抗菌药物应用情况。方法:随机抽选2016年2月—2018年8月本院收治的110例胆道感染患者为研究对象,分别对其胆道感染标本中的细菌进行检验、分离培养,做细菌学鉴定和药敏试验,分析细菌感染的分布特点以及耐药性。结果:110例胆道感染患者中共检测出病原菌85株,其中革兰氏阴性菌51株,革兰氏阳性菌27株,真菌7株。经耐药性分析后,革兰氏阴性菌对亚胺培南、美罗培南、阿米卡星的耐药性较低,对左氧氟沙星、氨苄西林、庆大霉素的耐药性较高。结论:胆道感染患者的致病病菌主要是革兰氏阴性杆菌,对左氧氟沙星、氨苄西林、庆大霉素具有较高的耐药性,临床治疗时要严格根据细菌分布特点并结合其耐药情况合理用药。Objective:To analyze the bile bacterial culture and application of antibiotics in patients with biliary tract infection.Methods:110 patients with biliary tract infection in the hospital from February 2016 to August 2018 were randomly selected as research subjects.The bacteria in the specimens of biliary tract infection were examined,isolated and cultured,and the bacterial identification and drug sensitivity test were performed to analyze the distribution characteristics and drug resistance of bacterial infection.Results:A total of 85 strains of pathogenic bacteria were detected in 110 patients with biliary tract infection,including 51 strains of Gram-negative bacteria,27 strains of Gram-positive bacteria,and 7 strains of fungi.After resistance analysis,Gram-negative bacteria had lower drug resistance to imipenem,meropenem and amikacin,and had higher drug resistance to levofloxacin,ampicillin and gentamicin.Conclusion:The pathogenic bacteria of patients with biliary tract infection are mainly Gram-negative bacilli,which have higher drug resistance to levofloxacin,ampicillin and gentamicin.In clinical treatment,it is necessary to conduct rational drug administration according to the distribution characteristics of bacteria and their drug resistance.

关 键 词：胆道感染 胆汁细菌培养 抗菌药物 耐药性 

分 类 号：R969.4[医药卫生—药理学]