Synbiological systems for complex natural products biosynthesis  

作　　者：Jianhua Li Hailin Meng Yong Wang 

机构地区：[1]Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China [2]Bioengineering Research Center,Guangzhou Institute of Advanced Technology,Chinese Academy of Sciences,Guangzhou 511458,China

出　　处：《Synthetic and Systems Biotechnology》2016年第4期221-229,共9页合成和系统生物技术（英文）

基　　金：the National Basic Research Program of China(“973”Program,grant No.2012CB721104);the National Natural Science Foundation of China(grant No.31170101).

摘　　要：Natural products(NPs)continue to play a pivotal role in drug discovery programs.The rapid development of synthetic biology has conferred the strategies of NPs production.Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways.However,there is still a challenge for integrating a heterologous pathway in chassis cells for overproduction purpose due to the limited characterized parts,modules incompatibility,and cell tolerance towards product.Enormous endeavors have been taken for mentioned issues.Herein,in this review,the progresses in naturally discovering novel biological parts and rational design of synthetic biological parts are reviewed,combining with the advanced assembly technologies,pathway engineering,and pathway optimization in global network guidance.The future perspectives are also presented.

关 键 词：Natural products Synbiological system Synthetic biology Biological parts Systematic optimization 

分 类 号：F42[经济管理—产业经济]