Systems metabolic engineering strategies for the production of amino acids  

作　　者：Qian Ma Quanwei Zhang Qingyang Xu Chenglin Zhang Yanjun Li Xiaoguang Fan Xixian Xie Ning Chen 

机构地区：[1]National and Local United Engineering Lab of Metabolic Control Fermentation Technology,Tianjin University of Science and Technology,Tianjin,300457,China [2]Key Laboratory of Industrial Fermentation Microbiology,Ministry of Education,Tianjin University of Science and Technology,Tianjin,300457,China [3]College of Biotechnology,Tianjin University of Science and Technology,Tianjin,300457,China

出　　处：《Synthetic and Systems Biotechnology》2017年第2期87-96,共10页合成和系统生物技术（英文）

基　　金：This research was supported by National High Technology Research and Development Program of China(2015AA021003);National Natural Science Foundation of China(31470211);Natural Science Foundation of Tianjin(17JCQNJC09500);Foundation(No.2016IM104)of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education and Tianjin Key Lab of Industrial Microbiology(Tianjin Universityof Science&Technology).

摘　　要：Systems metabolic engineering is a multidisciplinary area that integrates systems biology,synthetic biology and evolutionary engineering.It is an efficient approach for strain improvement and process optimization,and has been successfully applied in the microbial production of various chemicals including amino acids.In this review,systems metabolic engineering strategies including pathwayfocused approaches,systems biology-based approaches,evolutionary approaches and their applications in two major amino acid producing microorganisms:Corynebacterium glutamicum and Escherichia coli,are summarized.

关 键 词：Systems metabolic engineering Amino acid Corynebacterium glutamicum Escherichia coli 

分 类 号：O62[理学—有机化学]