Studies on the cytocompatibility,mechanical and antimicrobial properties of 3D printed poly(methyl methacrylate)beads  

作　　者：David K.Mills Uday Jammalamadaka Karthik Tappa Jeffery Weisman 

机构地区：[1]Center for Biomedical Engineering and Rehabilitation Science,USA [2]The School of Biological Sciences,Louisiana Tech University,Ruston,LA 71272,USA

出　　处：《Bioactive Materials》2018年第2期157-166,共10页生物活性材料（英文）

基　　金：This work was partially funded by the Louisiana Governor's Biotechnology Initiative,The Lagniappe Ladies Fund and a Louisiana Board of Regents Prototype/Proof-of-Concept grant.

摘　　要：Osteomyelitis is typically a bacterial infection(usually from Staphylococcus)or,more rarely,a fungal infection of the bone.It can occur in any bone in the body,but it most often affects the long bones(leg and arm),vertebral(spine),and bones of the foot.Microbial success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective agents.Also,biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a challenge.The development of local antibiotic delivery systems that deliver high concentrations of antibiotics to the affected site is an emerging area of research with great potential.Standard treatment includes antibiotic therapy,either locally or systemically and refractory cases of osteomyelitis may lead to surgical intervention and a prolonged course of antibiotic treatment involving placement of antibiotic-doped beads or spacers within the wound site.There are disadvantages with this treatment modality including insufficient mixing of the antibiotic,lack of uniform bead size,resulting in lower antibiotic availability,and limitations on the antibiotics employed.Thus,a method is needed to address biofilm formations in the wound and on the surface of the surgical implants to prevent osteomyelitis.In this study,we show that all antibiotics studied were successfully doped into PMMA and antibiotic-doped 3D printed beads,disks,and filaments were easily printed.The growth inhibition capacity of the antibiotic-loaded PMMA 3D printed constructs was also demonstrated.

关 键 词：3D printing ANTIBACTERIALS Drug delivery Halloysite nanotubes Medical devices NANOTECHNOLOGY 

分 类 号：O63[理学—高分子化学]