PDX-1/MafA与 Akt/PKB通路调控NIDDM发病机理  

PDX-1/MafA and Akt/PKB Signal Pathways Regulation of the Pathogenesis of NIDDM

作　　者：李凤林 刘静雪 谢天 马龙 代娇 Li Fenglin;Liu Jingxue;Xie Tian;Ma Long;Dai Jiao(College of Food Science,Jilin Agricultural Science and Technology University,Jilin 132101,Jilin,China;Brewing Technology Innovation Center of Jilin Province,Jilin 132101,Jilin,China)

机构地区：[1]吉林农业科技学院食品工程学院,吉林吉林132101 [2]吉林省酿造技术科技创新中心,吉林吉林132101

出　　处：《梧州学院学报》2020年第6期16-23,共8页Journal of Wuzhou University

基　　金：吉林省科技厅重点研发项目(20200402065NC);吉林农业科技学院食品科学与工程重点学科培育项目(2019X2001);吉林农业科技学院营养与健康食品科研团队经费资助。

摘　　要：非胰岛素依赖型糖尿病(NIDDM)是一种复杂和多因素的代谢性疾病,胰岛素抵抗(IR)被认为是引发NIDDM的始发因素。近年来,NIDDM的发病及调控机制已被大量研究。该文综述了PDX-1/MafA、Akt/PKB信号通路在NIDDM发病机理中的作用,以期从分子层面上筛选治疗NIDDM的天然产物(NPs),这将为NPs作为强化剂在低GI食物中进行营养强化,开发适合NIDDM患者食用的低GI-NPs食物提供理论依据。Non-insulin-dependent diabetes mellitus(NIDDM)is a complex and multi-factorial metabolic disease.IR is considered to be the initiating factor caused by NIDDM.In recent years,the pathogenesis and regulation mechanism of NIDDM have been extensively studied.This paper makes a review of the role of PDX-1/MafA and Akt/PKB signaling pathways in the pathogenesis of NIDDM,and provides technical support for screening natural products(NPs)for the treatment of NIDDM at the molecular level.This will provide a theoretical basis for NPs as a fortifier to fortify low-GI foods and develop low-GI-NPs foods suitable for NIDDM patients.

关 键 词：非胰岛素依赖型糖尿病 肌腱膜纤维肉瘤癌基因同系物A 胰岛素促进因子-1 Akt 发病机理 信号通路 

分 类 号：R587.1[医药卫生—内分泌]