The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms  

作　　者：Shan Wang Hai Deng 

机构地区：[1]Department of Chemistry,University of Aberdeen,Aberdeen,Scotland,AB243UE,United Kingdom

出　　处：《Synthetic and Systems Biotechnology》2020年第1期19-20,共2页合成和系统生物技术（英文）

基　　金：This work was supported by Biotechnology and Biological Sciences Research Council(BBSRC)award(BB/P00380X/1)to H.D.

摘　　要：Natural products have been an unprecedented starting point for drug and agrochemical discovery.They represent the only validated source of chemical diversity capable of delivering a sustainable pipeline for novel drug candidates.As of 1990,80%of clinically used drugs were natural products or natural product-inspired or semi-synthetic derivatives.From 1994 to 2007,almost half of the new chemical entities approved by FDA were based on natural products[1].By the end of 2013,natural products or their inspired compounds comprised about 40%of the FDA approved drugs[2].Streptomyces are by far the most prolific natural product producing organisms and as such this genus has been the research subjects for lead compound discovery for decades.

关 键 词：drugs STARTING approved 

分 类 号：R28[医药卫生—中药学]