In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups  

作　　者：Norsyahidah Mohd Hidzir David J.T.Hill Darren Martin Lisbeth Grøndahl 

机构地区：[1]School of Chemistry and Molecular Biosciences,University of Queensland,St Lucia,QLD,4072,Australia [2]Australian Institute for Bioengineering and Nanotechnology,University of Queensland,St Lucia,QLD,4072,Australia [3]School of Applied Physics,Faculty of Science&Technology,Universiti Kebangsaan Malaysia,UKM Bangi,Selangor,43600,Malaysia

出　　处：《Bioactive Materials》2017年第1期27-34,共8页生物活性材料（英文）

摘　　要：In vitro mineralisation in simulated body fluid(SBF)of synthetic polymers continues to be an important area of research as the outcomes cannot be predicted.This study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers,specifically using acrylic acid and itaconic acid for grafting.The samples differ with regards to graft density,carboxylate density and polymer topology.The type and amount of mineral produced in 1.5×SBF was dependent on the sample characteristics as evident from XPS,SEM/EDX,and FTIR spectroscopy.It was found that the graft density affects the mineral phases that form and that low graft density appear to cause co-precipitation of calcium carbonate and calcium phosphate.Linear and branched graft copolymer topology led to hydroxyapatite mineralisation whereas crosslinked graft copolymers resulted in formation of a mixture of calcium-phosphate phases.This study demonstrates that in vitro mineralisation outcomes for carboxylate-containing graft copolymers are complex.The findings of this study have implications for the design of bioactive coatings and are important for understanding the bone-biomaterial interface.

关 键 词：Simulated body fluid Expanded poly(tetrafluoroethylene) Graft copolymerisation Carboxylate groups 

分 类 号：O63[理学—高分子化学]