Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect  

作　　者：Wenlong Liu Ting Wang Xiaoli Zhao Xiuli Dan William W.Lu Haobo Pan 

机构地区：[1]Research Center for Human Tissue and Organs Degeneration,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China [2]Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma,Department of Orthopaedics,The University of Hong Kong-Shenzhen Hospital,University of Hong Kong,Shenzhen,China [3]School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong [4]Department of Orthopaedics and Traumatology,Faculty of Medicine,The University of Hong Kong,Hong Kong

出　　处：《Bioactive Materials》2016年第2期151-159,共9页生物活性材料（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.51272274,81672227,51372170);Shenzhen Peacock Program(No.110811003586331);Shenzhen Science and Technology Research funding(No.CXZZ 20150401152251209,JSGG20151030140325149,JSGG20150331154931068,CXZZ20140417113430716)and partially from Hong Kong General Research Fund.

摘　　要：In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated boneregeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic wasemployed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficialions (e.g. Mg^2+ ect.) released by the implants and the weak alkaline microenvironment pH (μe-pH) itcreated may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblasticanabolic effects. The performance of Ak, b-tricalcium phosphate (β-TCP) and Hardystone (Har) in healinga 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our resultsindicated that, there's more new bone formed in Ak group than in β-TCP or Har group at week 9. Theinitial me-pHs of Ak were significantly higher than that of the β-TCP and Blank group, and this weakalkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity whichwas indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediatelayer which was rich in phosphorus minerals and bound directly to the new forming bone wasdeveloped on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior boneregenerative performance under osteoporosis condition, and might be a promising candidate for thetreatment of osteoporotic bone defect and fracture.

关 键 词：Osteoporotic bone defect AKERMANITE Material-bone interface Microenvironment pH 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]