3D printing of Mg-substituted wollastonite reinforcing diopside porous bioceramics with enhanced mechanical and biological performances  

作　　者：Dongshuang He Chen Zhuang Sanzhong Xu Xiurong Ke Xianyan Yang Lei Zhang Guojing Yang Xiaoyi Chen Xiaozhou Mou An Liu Zhongru Gou 

机构地区：[1]Bio-nanomaterials and Regenerative Medicine Research Division,Zhejiang-California International Nanosystem Institute,Zhejiang University,Hangzhou,310058,China [2]Department of Orthopaedic Surgery,The First Affiliated Hospital,School of Medicine of Zhejiang University,Hangzhou,310003,China [3]Rui'an People's Hospital,The 3rd Hospital Affiliated to Wenzhou Medical College,Rui'an,325200,China [4]Clinical Research Institute,Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang,310014,PR China [5]Department of Orthopaedic Surgery,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310009,China

出　　处：《Bioactive Materials》2016年第1期85-92,共8页生物活性材料（英文）

基　　金：This work was supported by the Zhejiang Provincial Natural Science Foundation of China(LZ14E020001,LQ14H060003);gs2:National Science Foundation of China(51372218,81271956,81301326);the Science and Technology Department of Zhejiang Province Foundation(2015C33119,2014C33202).

摘　　要：Mechanical strength and its long-term stability of bioceramic scaffolds is still a problem to treat the osteonecrosis of the femoral head.Considering the long-term stability of diopside(DIO)ceramic but poor mechanical strength,we developed the DIO-based porous bioceramic composites via dilute magnesium substituted wollastonite reinforcing and three-dimensional(3D)printing.The experimental results showed that the secondary phase(i.e.10%magnesium substituting calcium silicate;CSM10)could readily improve the sintering property of the bioceramic composites(DIO/CSM10-x,x=0-30)with increasing the CSM10 content from 0%to 30%,and the presence of the CSM10 also improved the biomimetic apatite mineralization ability in the pore struts of the scaffolds.Furthermore,the flexible strength(12.5 -30 MPa)and compressive strength(14-37 MPa)of the 3D printed porous bioceramics remarkably increased with increasing CSM10 content,and the compressive strength of DIO/CSM10-30 showed a limited decay(from 37 MPa to 29 MPa)in the Tris buffer solution for a long time stage(8 weeks).These findings suggest that the new CSM10-reinforced diopside porous constructs possess excellent mechanical properties and can potentially be used to the clinic,especially for the treatment of osteonecrosis of the femoral head work as a bioceramic rod.

关 键 词：DIOPSIDE Dilute magnesium substituting wollastonite Mechanical properties Porous bioceramics 3D printing Osteonecrosis of the femoral head 

分 类 号：R31[医药卫生—基础医学]