An overview of graphene-based hydroxyapatite composites for orthopedic applications  

作　　者：Ming Li Pan Xiong Feng Yan Sijie Li Changhong Ren Zhichen Yin Ang Li Huafang Li Xunming Ji Yufeng Zheng Yan Cheng 

机构地区：[1]China-America Institute of Neuroscience,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China [3]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine,Xuanwu Hospital of Capital Medical University,Beijing 100053,China [4]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [5]Department of Biomedical Engineering,Columbia University,New York,NY 10032,USA [6]Musculoskeletal Research Laboratory,Department of Orthopaedics&Traumatology,The Chinese University of Hong Kong,Hong Kong Special Administrative Region

出　　处：《Bioactive Materials》2018年第1期1-18,共18页生物活性材料（英文）

基　　金：This work was supported by National Natural Science Foundation of China(No.31370954,31670974);Beijing Natural Science Foundation(2164073).

摘　　要：Hydroxyapatite(HA)is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite.However,its low fracture toughness,poor tensile strength and weak wear resistance become major obstacles for potential clinical applications.One promising method to tackle with these problems is exploiting graphene and its derivatives(graphene oxide and reduced graphene oxide)as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders,coatings and scaffolds.The last few years witnessed increasing numbers of studies on the preparation,mechanical and biological evaluations of these novel materials.Herein,various preparation techniques,mechanical behaviors and toughen mechanism,the in vitro/in vivo biocompatible analysis,antibacterial properties of the graphene-based HA composites are presented in this review.

关 键 词：GRAPHENE HYDROXYAPATITE COMPOSITES Bone tissue Biomedical devices 

分 类 号：TB3[一般工业技术—材料科学与工程]