From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading  

作　　者：Tong Yang Zeyu Du Hua Qiu Peng Gao Xin Zhao Huaiyu Wang Qiufen Tu Kaiqin Xiong Nan Huang Zhilu Yang 

机构地区：[1]Key Laboratory of Advanced Technology for Materials of the Education Ministry,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China [2]Department of Biomedical Engineering,The Hong Kong Polytechnic University,Hung Hom,Hong Kong,China [3]Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China

出　　处：《Bioactive Materials》2020年第1期17-25,共9页生物活性材料（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Project 31570957);the National Key Research and Development Program of China(2017YFB0702504);International Cooperation Project by Science and Technology Department of Sichuan Province(2019YFH0103);Applied Basic Research Project funded by Sichuan Provincial Science and Technology Department(2017JY0296).

摘　　要：Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications.However,the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites.Herein,we propose a novel concept of film engineering strategy“from surface to bulk synergetic modification”.This new concept is realized by employing the surface amine groups of plasma polymerized allylamine(PPAm)film for grafting a molecule e.g.,thrombin inhibitor,bivalirudin(BVLD),meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide(NO)gas as supplement to the functions of BVLD.It is demonstrated that such a“from surface to bulk synergetic modification”film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions,giving rise to a highly endotheliummimetic thromboresistant property.We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties,which will find broad biomedical applications in blood-contacting devices,and et al.Moreover,it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials.

关 键 词：Surface chemistry Amine-bearing coating Synergic modification Biomolecule grafting Nitric oxide loading 

分 类 号：TB30[一般工业技术—材料科学与工程]