生大黄与清蒸大黄的大承气汤对血清内毒素、NO和TNF-α含量变化的影响  

Effect of Dachengqi decoction of raw rhubarb and steamed rhubarb on changes of serum endotoxin,NO and TNF-αcontent

作　　者：杨桂林 刘承统[1] 曾海生[1] 何思陆[1] 周歧骥 莫昕莹 陈冬莲 陆玉丹 YANG Gui-lin;LIU Cheng-tong;ZENG Hai-sheng;HE Si-lu;ZHOU Qi-ji;MO Xin-ying;CHEN Dong-lian;LU Yu-dan(Affiliated Hospital of Youjiang Medical College for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院,广西百色533000

出　　处：《湖北农业科学》2021年第1期96-99,146,共5页Hubei Agricultural Sciences

基　　金：广西壮族自治区中医药管理局科研课题(GZZC2019147);右江民族医学院附属医院2019年度第一批高层次人才科研项目(Y20196311);右江民族医学院校级科研项目(yy2018ky018);2019年广西中医药大学青年基金项目(2019QN036)。

摘　　要：为研究生大黄(Rheum officinale Baill.)与清蒸大黄的大承气汤对血清内毒素、NO和肿瘤坏死因子(TNF-α)含量变化的影响,将105只实验动物随机分为生大黄与清蒸大黄的大承气汤组、阳性对照组、空白对照组及模型组,按20 mL/kg的剂量给药后,测定血清内毒素、一氧化氮和肿瘤坏死因子的含量,比较生大黄与清蒸大黄的大承气汤对小鼠血清内毒素、一氧化氮和肿瘤坏死因子含量的影响。结果表明,生大黄与清蒸大黄的大承气汤组都能增加ABP小鼠血清NO含量;生大黄与清蒸大黄的大承气汤组都能降低ABP小鼠血清内毒素和TNF-ɑ含量。生大黄与清蒸大黄的大承气汤对血清内毒素、NO和TNF-ɑ的含量均有不同程度的影响,这些变化与生大黄与清蒸大黄的大承气汤作用相对应,且大黄蒽醌类成分含量的变化在一定程度上对大承气汤的功效存在着一定的影响和共性关系。Aiming to study the effect of Dachengqi decoction of raw rhubarb and steamed rhubarb on serum endotoxin,NO and TNF-αlevels,105 experimental animals were randomly divided into Dachengqi decoction group,positive control group,blank control group and model group with raw rhubarb and steamed rhubarb.After 20 mL/kg dose administration,the contents of serum endotoxin,nitric oxide and tumor necrosis factor were measured,and the effects of Dachengqi decoction of raw rhubarb and steamed rhubarb on serum endotoxin,nitric oxide and tumor necrosis factor in mice were compared.Result showed that,Dachengqi decoction group of raw rhubarb and steamed rhubarb can increase the serum NO content of ABP mice.The Dachengqi decoction group of raw rhubarb and steamed rhubarb can reduce the serum endotoxin and TNF-ɑcontent of ABP mice.Dachengqi decoction with raw rhubarb and steamed rhubarb has different effects on the content of endotoxin,NO and TNF-α.These changes correspond to the effect of Dachengqi decoction of raw rhubarb and steamed rhubarb,and the he change of the content of the ingredients has a certain influence and commonality on the efficacy of Dachengqi decoction to a certain extent.

关 键 词：大黄(Rheum officinale Baill.) 大承气汤 内毒素 一氧化氮 肿瘤坏死因子(TNF-α) 

分 类 号：S859.3[农业科学—临床兽医学]