质量平衡法测定盐酸海洛因纯度  

Determination of purity of heroin hydrochloride by mass balance method

作　　者：苏福海[1] 韦棋 Su Fuhai;Wei Qi(National Institute of Metrology of China,Beijing 100029,China)

机构地区：[1]中国计量科学研究院,北京100029

出　　处：《化学分析计量》2021年第2期51-55,共5页Chemical Analysis And Meterage

摘　　要：研究了盐酸海洛因纯度的定值技术。对经筛选的盐酸海洛因原料进行液相色谱–质谱、红外光谱、核磁及离子色谱定性分析,采用质量平衡法对盐酸海洛因原料进行纯度测定。在基于色谱的质量平衡法的基础上优化了检测条件,确定了主成分的含量,用卡尔费休法测定样品水分含量,最终得到盐酸海洛因纯度定值为95.1%。该分析结果的标准不确定度为0.32%。The purity certification technology of heroin hydrochloride was developed.After the qualitative analysis on crude material by liquid chromatography–mass spectrometry(LC–MS),infrared spectroscopy,1H nuclear magnetic resonance(1H NMR)and ion chromatography(IC),the purity of heroin hydrochloride was certified by mass balance method based on high performance liquid chromatography(HPLC)and gas chromatography(GC).The main component purity of heroin hydrochloride was measured by HPLC and GC.At the same time,water content was measured by Karl Fisher.The purity value of heroin hydrochloride was certified as 95.1%and the standard uncertainty was evaluated as 0.32%.

关 键 词：盐酸海洛因 色谱法 质量平衡法 不确定度评定 

分 类 号：O657.2[理学—分析化学]