噬菌体治疗细菌感染的研究进展  

Advances in the treatment of bacterial infections by phages

作　　者：伍亚云 黄勋[1] WU Ya-yun;HUANG Xun(Center for Healthcare-associated Infection Control,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院医院感染控制中心,湖南长沙410008

出　　处：《中国感染控制杂志》2021年第2期186-190,共5页Chinese Journal of Infection Control

基　　金：湖南省卫生厅重点课题基金资助项目(20201422)。

摘　　要：噬菌体是能特异性感染细菌的病毒,早在其被发现之初,就被用于治疗细菌感染。但随着抗生素的发现,及其高效、方便、便宜的特点,很快在世界各地广泛应用,因此关于噬菌体的研究也逐渐放缓。近年来,由于细菌耐药问题逐渐严重,多重耐药菌不断出现,寻找新的抗菌药物成为目前抗感染治疗方面的重点及趋势,曾经快被人们淡忘的噬菌体疗法又再次受到临床研究人员的重视。此文基于国内外噬菌体的研究现状,综合归纳了噬菌体在细菌感染治疗方面的应用,并分析了噬菌体疗法的优势和局限性。Phages are viruses that can infect bacteria specifically and have been used to treat bacterial infections since their discovery.However,with the discovery of antibiotics and their characteristics of high efficiency,conve-nience and low cost,antibiotics are widely used all over the world,so the research on phages have been slowed down gradually.In recent years,due to the increasingly serious problem of bacterial resistance and the emergence of multidrug-resistant organisms,the search for new antimicrobial agents has become the focus and trend of anti-infection treatment.As a result,phage therapy,which has been on the verge of oblivion,attracts the attention of clinical researchers again.Based on the current research on phages at home and abroad,this paper summarizes the application of phages in the treatment of bacterial infection,and analyzes the advantages and limitations of phage therapy.

关 键 词：噬菌体 细菌感染 耐药性 治疗应用 

分 类 号：R978[医药卫生—药品]