耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的效果及其对血浆Hcy水平的影响  

Effect of retroauricular injection of methylprednisolone sodium succinate in treatment of sudden deafness and its effect on serum Hcy level

作　　者：林颖 韦富贵 LIN Ying;WEI Fugui(Department of Otorhinolaryngology Head and Neck Surgery,the Second Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou,Guangxi 545005,China)

机构地区：[1]广西科技大学第二附属医院耳鼻喉头颈外科,广西柳州545005

出　　处：《重庆医学》2021年第2期211-214,共4页Chongqing medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2016032)。

摘　　要：目的探讨耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效及其对血清同型半胱氨酸(Hcy)水平的影响。方法选取2019年4月至2020年4月广西科技大学第二附属医院收治的突发性耳聋患者70例,按照随机数字表法分成A组(n=37)与B组(n=33)。A组采用地塞米松磷酸钠于耳后沟行乳突骨膜下注射治疗,B组采用泼尼龙琥珀酸钠行耳后沟乳突骨膜下注射治疗。比较两组治疗前后纯音听阈值、血清Hcy水平及血小板(PLT)计数,以及临床疗效与不良反应发生情况。结果B组治疗总有效率明显高于A组(96.97%vs.83.78%,P<0.05)。治疗后,两组纯音听阈值、血清Hcy水平及PLT计数均较治疗前明显降低(P<0.05),且B组明显低于A组(P<0.05)。A组与B组不良反应发生率无明显差异(10.81%vs.15.15%,P>0.05)。结论采用甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋,疗效好且安全,能明显改善患者听力。Objective To investigate the effect of retroauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness and its effect on serum homocysteine(Hcy).Methods A total of 70 patients with sudden deafness from April 2019 to April 2020 were randomly divided into group A(n=37)and group B(n=33).Group A was injected with dexamethasone sodium phosphate in posterior sulcus of ear,and group B was injected with prednisolone sodium succinate in posterior sulcus of ear.After treatment,pure tone threshold,serum Hcy level,and serum platelet(PLT)count,clinical efficacy and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of group B was higher than that of group A(96.97%vs.83.78%,P<0.05).The pure tone threshold,serum PLT count and Hcy level significantly decreased in the 2 groups(P<0.05),and group B was significantly lower than group A(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(10.81%vs.15.15%,P>0.05).Conclusion For patients with sudden deafness,methylprednisolone sodium succinate is safe and effective,which can significantly improve hearing.

关 键 词：突发性耳聋 甲泼尼龙琥珀酸钠 耳后注射 治疗结果 同型半胱氨酸 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]