Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application  被引量:6

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作  者:Sihui Ouyang Qianli Huang Yong Liu Zhengxiao Ouyang Luxin Liang 

机构地区:[1]State Key Lab of Powder Metallurgy,Central South University,Changsha,410083,PR China [2]Department of Orthopedics,The Second Xiangya Hospital,Central South University,Changsha,Hunan,PR China

出  处:《Bioactive Materials》2019年第1期37-42,共6页生物活性材料(英文)

基  金:the support from the National Natural Science Funds for Distinguished Young Scholar of China(51625404);China Postdoctoral Science Foundation(2018M630909).

摘  要:In this work,TieMg metal-metal composites(MMCs)were successfully fabricated by spark plasma sintering(SPS).In vitro,the proliferation and differentiation of SaOS-2 cells in response to TieMg metal-metal composites(MMCs)were investigated.In vivo,a rat model with femur condyle defect was employed,and TieMg MMCs implants were embedded into the femur condyles.Results showed that TieMg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti.The micro-computed tomography(Micro-CT)results showed that the volume of bone trabecula was significantly more abundant around TieMg implants than around Ti implants,indicating that more active new-bone formed around TieMg MMCs implants.Hematoxylin-eosin(H&E)staining analysis revealed significantly greater osteointegration around TieMg implants than that around Ti implants.

关 键 词:Powder metallurgy COMPOSITES OSTEOCONDUCTION OSSEOINTEGRATION 

分 类 号:TB3[一般工业技术—材料科学与工程]

 

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