艾灸对胃癌术后胃肠功能和营养状况及血清IL-8、TNF-α水平的影响  

Effect of Moxibustion on Gastrointestinal Functions,Nutritional Status and Serum IL-8 and TNF-αLevels After Gastric Cancer Surgery

作　　者：谢鹏 宁松毅 仇成华[2] 刘皓昕 尹五青 王洪梅 杨桃 陈华文 李利斌 XIE Peng;NING Song-yi;QIU Cheng-hua;LIU Hao-xin;YIN Wu-qing;WANG Hong-mei;YANG Tao;CHEN Hua-wen;LI Li-bin(School of Medicine,Jiangsu University,Zhenjiang 212023,China;Yancheng Hospital Affiliated to School of Medicine,Southeast University,Yancheng 224000,China;Xuzhou Hospital of Traditional Chinese Medicine,Xuzhou 221003,China)

机构地区：[1]江苏大学医学院,镇江212023 [2]东南大学医学院附属盐城医院,盐城224000 [3]徐州市中医院,徐州221003

出　　处：《上海针灸杂志》2021年第2期127-131,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：江苏省卫生计生委医学科研课题(H201785)。

摘　　要：目的观察术前艾灸对胃癌术后患者的胃肠功能和和营养状况的改善作用以及血清白细胞介素(IL)-8和肿瘤坏死因子(TNF)-α水平的影响。方法将行胃癌根治术102例患者纳为研究对象,用随机数字表法分为对照组和观察组,每组51例。两组患者胃癌根治术结束后均行常规干预措施。观察组患者在术前予艾灸足三里;对照组患者在术后予艾灸足三里。观察两组术后肛门首次排气、排便以及肠鸣音恢复时间、胃肠功能临床疗效、血清生长激素(GH)、白蛋白(ALB)、转铁蛋白(TRF)、IL-8和TNF-α水平。结果观察组患者术后的首次排气、排便时间以及肠鸣音恢复时间均明显短于对照组(P<0.01)。观察组和对照组患者临床疗效的优良率分别为60.8%和37.3%,两组比较差异有统计学意义(P<0.05)。治疗后,观察组血清GH、ALB、TRF水平较对照组升高更明显(P<0.05),观察组患者血清IL-8、TNF-α水平均明显低于对照组(P<0.05)。结论术前艾灸能促进胃癌术后患者的胃肠功能和营养状况的改善,提高胃肠功能,且可有效降低血清IL-8和TNF-α水平。Objective To investigate the effect of preoperative moxibustion on postoperative gastrointestinal functions,improvement in nutritional status and serum interleukin(IL)-8 and tumor necrosis factor(TNF)-αlevels in gastric cancer patients.Method One hundred and two patients with radical gastrectomy for cancer were enrolled as subjects and allocated,using a random number table,to control and observation groups,51 cases in each group.Both groups were given conventional interventions after the completion of radical gastrectomy for cancer.The observation group received moxibustion on Zusanli(ST36)before surgery and the control group received moxibustion on Zusanli after surgery.Postoperative first flatus time,first defecation time,time for bowel sound to recover,clinical effect on gastrointestinal functions,and serum growth hormone(GH),albumin(ALB)and transferrin(TRF)levels,and serum IL-8 and TNF-αlevels were observed in the two groups.Result Postoperative first flatus time,first defecation time and time for bowel sound to recover were significantly shorter in the observation group of patients than in the control group(P<0.01).The excellent and good rate of clinical therapeutic effect was 60.8%in the observation group and 37.3%in the control group,with a statistically significant difference between the two groups(P<0.05).After treatment,serum GH,ALB and TRF levels increased more significantly in the observation group than in the control group(P<0.05),and serum IL-8 and TNF-αlevels were significantly lower in the observation group than those in the control group(P<0.05).Conclusion Preoperative moxibustion can promote improvement in gastrointestinal functions and nutritional status,ameliorate gastrointestinal functions and reduce serum IL-8 and TNF-αlevels in gastric cancer patients after surgery.

关 键 词：灸法 艾条灸 温灸盒灸 胃肿瘤 手术后并发症 胃肠功能障碍 穴 足三里 

分 类 号：R246.5[医药卫生—针灸推拿学]