Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy  

作　　者：Zhenhu Guo Jingsong Lu Dan Wang Wensheng Xie Yongjie Chi Jianzhong Xu Nonaka Takuya Junxin Zhang Wanling Xu Fei Gao Hong Wu Lingyun Zhao 

机构地区：[1]State Key Laboratory of Powder Metallurgy,Powder Metallurgy Research Institute,Central South University,Changsha,Hunan,410083,China [2]Key Laboratory of Advanced Materials,Ministry of Education of China,School of Materials Science and Engineering,Tsinghua University,Beijing,100084,China [3]State Key Laboratory of New Ceramics and Fine Processing,School of Materials Science and Engineering,Tsinghua University,Beijing,100084,China [4]Research Center of Magnetic and Electronic Materials,College of Materials Science and Engineering,Zhejiang University of Technology,Hangzhou,Zhejiang,310014,China [5]Department of Nanoengineering,Chemical Engineering Program,and Moores Cancer Center,University of California San Diego,La Jolla,CA,92093,United States [6]The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing,100084,China [7]School of Earth Sciences and Resources,China University of Geosciences(Beijing),Beijing,100083,China [8]Shaanxi University of Chinese Medicine,Xi'an,Shanxi,712046,China

出　　处：《Bioactive Materials》2021年第3期602-612,共11页生物活性材料（英文）

基　　金：supported by grants of the National Natural Science Foundation of China(Nos.5197116,81671829).

摘　　要：With tremendous research advances in biomedical application,liquid metals(LM)also offer fantastic chemistry for synthesis of novel nano-composites.Herein,as a pioneering trial,litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles(EGaIn-Au NPs),served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy,have been successfully prepared using in situ interfacial galvanic replacement reaction.The enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium(EGaIn)NPs surface.Most importantly,the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au NPs.Inspired by this approach,in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities.

关 键 词：Au nanodots Gallium Galvanic replacement reaction Indium Radio-photothermal therapy 

分 类 号：R318.08[医药卫生—生物医学工程] R730.5[医药卫生—基础医学]