Microbial ingress and in vitro degradation enhanced by glucose on bioabsorbable Mg-Li-Ca alloy  

作　　者：Ling-Yu Li Zhuang-Zhuang Han Rong-Chang Zeng Wei-Chen Qi Xiao-Fan Zhai Yi Yang Yun-Tian Lou Tingyue Gu Dake Xu Ji-Zhou Duan 

机构地区：[1]Corrosion Laboratory for Light Metals,College of Material Science and Engineering,Shandong University of Science and Technology,Qingdao,266590,China [2]Institute of Oceanology,Chinese Academy of Sciences,Qingdao,266590,China [3]Shenyang National Laboratory for Materials Science,Northeastern University,Shenyang,110819,China [4]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou,450002,China [5]Department of Chemical&Biomolecular Engineering,Russ College of Engineering and Technology,Ohio University,Athens,OH,45701-2979,USA

出　　处：《Bioactive Materials》2020年第4期902-916,共15页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(51571134);Research Fund(2014TDJH104)of Shandong University of Science and Technology.

摘　　要：Biodegradable magnesium alloys are challenging to be implanted in patients with hyperglycemia and diabetes.A hypothesis is suggested that glucose accelerates microbial ingress and in vitro degradation of Mg-Li-Ca implants.Corrosion resistance and mechanical properties was demonstrated using electrochemical,hydrogen evolution and tensile tests.The bacteria from Hank's solution were isolated via 16S rRNA gene analysis.The results revealed that Mg-1Li-1Ca alloy exhibited different responses to Hank's solution with and without glucose.The solution acidity was ascribed to Microbacterium hominis and Enterobacter xiangfangensis,indicating that glucose promoted microbial activity and degradation and deterioration in mechanical property of Mg-1Li-1Ca alloy.

关 键 词：GLUCOSE Magnesium Bacteria Biomaterial BIODEGRADATION 

分 类 号：TG14[一般工业技术—材料科学与工程]