Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition  

作　　者：Zhiguo Lu Jianze Wang Lina Qu Guanghan Kan Tianlu Zhang Jie Shen Yan Li Jun Yang Yunwei Niu Zuobing Xiao Yinghui Li Xin Zhang 

机构地区：[1]State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing,100190,PR China [2]State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center,Beijing,100094,China [3]School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing,100049,PR China [4]Shanghai Research Institute of Fragrance and Flavor Industry,Shanghai,200232,PR China [5]School of Perfume and Aroma Technology,Shanghai Institute of Technology,Shanghai,200233,PR China

出　　处：《Bioactive Materials》2020年第4期1127-1137,共11页生物活性材料（英文）

基　　金：financially supported by the National High Technology Research and Development Program(2016YFA0200303);the Beijing Natural Science Foundation(L172046,2192057);the National Natural Science Foundation of China(31771095,21875254 , 21905283).

摘　　要：Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of astronauts.Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently.However,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight.In this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene.The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy.LE@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the wallpaper.In the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity environment.The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in mice.LE@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated mice.Subsequently,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins.

关 键 词：Reactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health 

分 类 号：TB383[一般工业技术—材料科学与工程]