依折麦布联合洛伐他汀对急性脑梗死的疗效及颈动脉内膜中层厚度等的影响  

Effect of ezetimibe combined with lovastatin on acute cerebral infarction and carotid intima membrane thickness

作　　者：谭忠兵 夏乐[1] 管义祥 TAN Zhongbing;XIA Le;GUAN Yixiang(Department of Emergency Medicine,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China;Department of Neurology,Haian People′s Hospital,Haian 226600,China)

机构地区：[1]扬州大学附属医院急诊医学科,扬州225000 [2]海安市人民医院神经科,海安226600

出　　处：《西北药学杂志》2021年第1期135-139,共5页Northwest Pharmaceutical Journal

基　　金：江苏省“333”工程科研资助项目(编号:BRA2016187)。

摘　　要：目的观察依折麦布联合洛伐他汀治疗急性脑梗死的疗效及对颈动脉内膜中层厚度(IMT)、血脂水平及血清炎性因子水平的影响。方法选取106例急性脑梗死患者,用随机数字表法随机均分为研究组和对照组。对照组患者给予常规治疗及洛伐他汀治疗,研究组给予常规治疗及洛伐他汀联合依折麦布治疗,治疗3个月后评价2组患者的治疗效果及治疗前后患者颈动脉IMT、血脂水平和血清炎性因子水平的变化情况。结果所有患者均顺利完成治疗,无因不良反应而停药的患者。治疗3个月后,对照组的总有效率为77.36%,研究组为92.45%,研究组明显高于对照组(P<0.05)。对照组和研究组的总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)比治疗前均明显降低,研究组的高密度脂蛋白胆固醇(HDL-C)相比治疗前和对照组治疗后均显著升高(P<0.05),且研究组的TC和LDL-C较对照组明显降低(P<0.05),2组治疗后的三酰甘油(TG)相比治疗前差异无统计学意义(P>0.05)。研究组的血脂LDL-C达标率比对照组明显升高(P<0.05)。研究组患者颈动脉IMT及血清炎症因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)相比治疗前和对照组治疗后均显著降低,对照组的颈动脉IMT和上述血清炎性因子相比治疗前也明显降低(P<0.05)。结论对急性脑梗死患者在常规治疗基础上联合应用依折麦布和洛伐他汀比单纯应用洛伐他汀能更明显地降低患者的TC和LDL-C,升高HDL-C,还能显著降低患者颈动脉IMT和血清炎症因子水平,提高治疗效果,有良好的安全性。Objective To observe the therapeutic effect of ezetimibe combined with lovastatin on acute cerebral infarction and its effect on carotid intima-media thickness(IMT),blood lipid level and serum inflammatory factor level.Methods A total of 106 patients with acute cerebral infarction were selected as the research subjects,and randomly divided into the study group and the control group by random number table.Patients in the control group were given conventional treatment and lovastatin treatment.Patients in the study group were given conventional treatment plus lovastatin and ezetimibe treatment.After 3 months of treatment,the treatment effect of the 2 groups of patients was evaluated and the carotid IMT,the levels of serum inflammatory factor and blood lipids of the patients were evaluated.Results All patients successfully completed the treatment,and no patients discontinued due to adverse reactions.The overall effective rate of the control group after 3 months of treatment was 77.36%and that of the study group was 92.45%.Compared with the control group,the research group was significantly higher(P<0.05).After treatment,the total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)of the control group and the study group were significantly lower than those before treatment,and the high-density lipoprotein cholesterol(HDL-C)of the study group after treatment were significantly higher than those before and after the treatment of the control group(P<0.05),and the TC and LDL-C in the study group after treatment were significantly lower than those in the control group(P<0.05).There was no significant difference in triglyceride(TG)between the 2 groups before and after treatment(P>0.05).The blood lipid LDL-C compliance rate in the study group after 3 months of treatment was also significantly increased in the control group(P<0.05).The IMT of carotid artery and serum inflammatory factors high sensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the study group were signific

关 键 词：依折麦布 洛伐他汀 急性脑梗死 颈动脉内膜中层厚度 血脂 炎症因子 

分 类 号：R972[医药卫生—药品]