In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations  

作　　者：M.A.Goldberg P.A.Krohicheva A.S.Fomin D.R.Khairutdinova O.S.Antonova A.S.Baikin V.V.Smirnov A.A.Fomina A.V.Leonov I.V.Mikheev N.S.Sergeeva S.A.Akhmedova S.M.Barinov V.S.Komlev 

机构地区：[1]A.A.Baikov Institute of Metallurgy and Materials Science,Russian Academy of Sciences,119334,Leninsky av,49,Moscow,Russian Federation [2]M.V.Lomonosov Moscow State University,Department of Chemistry,119991,Leninskie Gory,1,Moscow,Russian Federation [3]Federal State Budgetary Institution National Medical Research Radiological Center of the Ministry of Health of the Russian Federation,125284,2nd Botkinsky pass.,3,Moscow,Russian Federation

出　　处：《Bioactive Materials》2020年第3期644-658,共15页生物活性材料（英文）

基　　金：financially support by Russian Foundation for Basic Research(Grant No.18-33-20170).

摘　　要：Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded.Nevertheless,they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate.Struvite(MgNH4PO4)-based cements,which grew in popularity in recent years,despite their neutral pH and acceptable mechanical performance,release undesirable NH4+ions during their resorption.This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium,however,such cements have a pH values of 9–10,leading to cytotoxicity.Thus,the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties:neutral pH,sufficient mechanical properties,and the absence of cytotoxicity,applying Na2HPO4-based cement liquid.For this purpose,cement powders precursors in the CaO-MgO-P2O5 system were synthesized by one-pot process in a wide composition range,and their properties were investigated.The optimal performance was observed for the cements with(Ca+Mg)/P ratio of 1.67,which are characterized by newberyite phase formation during setting reaction,pH values close to 7,sufficient compressive strength up to 22±3 MPa(for 20 mol.%of Mg),dense microstructure and adequate matrix properties of the surface.This set of features make those materials promising candidates for medical applications.

关 键 词：Magnesium calcium phosphate cement Stanfieldite Whitlockite Newberyite BRUSHITE In vitro investigations 

分 类 号：R318.08[医药卫生—生物医学工程]