Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications  

作　　者：Wei Xu Chenjin Hou Yuxuan Mao Lei Yang Maryam Tamaddon Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Xin Lu 

机构地区：[1]Beijing Advanced Innovation Center for Materials Genome Engineering,State Key Laboratory for Advanced Metals and Materials,Institute for Advanced Materials and Technology,University of Science and Technology Beijing,Beijing,China [2]Institute of Orthopaedic&Musculoskeletal Science,University College London,Royal National Orthopaedic Hospital,Stanmore,HA74LP,UK [3]Center for Health Science and Engineering,Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology,School of Materials Science and Engineering,Hebei University of Technology,Tianjin,300130,China [4]School of Metallurgical and Ecological Engineering,University of Science and Technology Beijing,Beijing,100083,China [5]Bristol Dental School,University of Bristol,Bristol,BS12LY,UK

出　　处：《Bioactive Materials》2020年第3期659-666,共8页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(51922004,51874037,51672184);State Key Lab of Advanced Metals and Materials,University of Science and Technology Beijing(2019-Z14);Fundamental Research Funds for the Central Universities(FRF-TP-19005C1Z);the support from the European Commission via the H2020 MSCA RISE BAMOS programme(734156);Bo Su would like to thank financial support from the MRC(MR/S010343/1);the EU H2020 MSCA RISE Bio-TUNE programme;the support from the China Scholarship Council(CSC)for a CSC Ph.D.scholarship(201906460106).

摘　　要：When biomaterials are implanted in the human body,the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation,causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery.Ti-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement,and the prevention of infection of Ti-Mo implants is therefore crucial.In this study,bacterial inhibitory copper(Cu)was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory property.The effects of Cu content on microstructure,tensile properties,cytocompatibility,and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically investigated.Results revealed that Ti-10Mo-1Cu alloy consisted ofαandβphases,while there were a few Ti2Cu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys,in addition toαandβphases.The tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation decreased.Ti-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%.Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation.Bacterial inhibitory rates against S.aureus and E.coli increased with the increase in Cu content of Ti-10Mo-xCu alloy,within the ranges of 20-60%and 15-50%,respectively.Taken together,this study suggests that Ti-10Mo-3Cu alloy with high strength,acceptable elongation,excellent cytocompatibility,and the bacterial inhibitory property is a promising candidate for biomedical implant applications.

关 键 词：Ti-10Mo-xCu alloy Microstructure Mechanical properties CYTOCOMPATIBILITY Bacterial inhibitory property 

分 类 号：TG13[一般工业技术—材料科学与工程]