Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer  

作　　者：Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou 

机构地区：[1]Institute of Bismuth Science,University of Shanghai for Science and Technology,Shanghai,200093,China [2]Cancer Institute,Tongji University School of Medicine,Shanghai,200092,China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,453007,China

出　　处：《Bioactive Materials》2021年第2期386-403,共18页生物活性材料（英文）

基　　金：This work was financially supported by the Natural Science Foundation of Shanghai(19ZR1434800,19ZR1461900);the National Natural Science Foundation of China(21305090);the Fundamental Research Funds for the Central Universities(to Shuang Zhou);The authors greatly appreciated these supports.

摘　　要：To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy.

关 键 词：Au@Bi2S3 NBs DOX CT Photothermal conversion Cancer treatment 

分 类 号：R318[医药卫生—生物医学工程] R730.5[医药卫生—基础医学]