Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia  

作　　者：Zhoujun Wang Wei Sun Zhiwei Wei Jianxu Bao Xin Song Yupei Li Haifeng Ji Jue Zhang Chao He Baihai Su Weifeng Zhao Changsheng Zhao 

机构地区：[1]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu,610065,China [2]Laboratory Department of General Hospital of Western Theatek Command,Chengdu,610000,China [3]Department of Nephrology,West China Hospital,Sichuan University,Chengdu,610041,China [4]Institute for Disaster Management and Reconstruction,Sichuan University,Chengdu,610207,China [5]College of Chemical Engineering,Sichuan University,Chengdu,610065,China [6]College of Biomedical Engineering,Sichuan University,Chengdu,610064,China

出　　处：《Bioactive Materials》2021年第2期543-558,共16页生物活性材料（英文）

基　　金：This work was financially sponsored by the State Key Research Development Programme of China(Grant No.2016YFC1103000);the National Natural Science Foundation of China(No.51773127,51873115);Science and Technology Program of Sichuan Province(2019YJ0132);We gratefully acknowledge the help of the Analytical and Testing Center at Sichuan University for the SEM and XPS analysis.

摘　　要：Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various lifethreatening complications.Treatments primarily rely on orally administered potassium binding agents,along with low curative effects and various side effects.Herein,direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads.The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution,the fabrication of microbeads via zeolite-mixing,electro-spraying and phase-inversion,and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching.An ultra-high(about 88%)amount of zeolite could be incorporated and well locked inside the polymer matrix.Potassium uptake capability was verified in water,normal saline and human serum,showing high selectivity and fast adsorption.The microbeads exhibited satisfying blood compatibility,negligible hemolysis ratio,prolonged clotting time,inhibited contact activation,and enhanced antifouling property toward serum proteins and cells.The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap,efficient and safe treatment protocol of hyperkalemia for the high-risk patients.

关 键 词：Potassium uptake Competitive adsorption Microbead ZEOLITE Blood compatibility 

分 类 号：R318[医药卫生—生物医学工程]