重组人干扰素α-1b联合更昔洛韦治疗传染性单核细胞增多症患儿的临床效果及其对患儿免疫力的影响  

Clinical Efficacy of Recombinant Human Interferon Alpha-1b combined with Ganciclovir in the Treatment of InfectiousMononucleosis in Children and Its Influence on Immunity

作　　者：杨波 YANG Bo(Department of Pediatrics,Lingyuan Central Hospital,Lingyuan 122500,China)

机构地区：[1]凌源市中心医院儿科,辽宁凌源122500

出　　处：《中国医药指南》2020年第36期10-12,共3页Guide of China Medicine

摘　　要：目的探析重组人干扰素α-1b联合更昔洛韦治疗传染性单核细胞增多症(IM)患儿的临床效果及对患儿免疫力的影响,以期为临床医师选择合理用药方案提供参考。方法选取2015年3月至2018年2月本院收治的78例IM患儿作为研究对象,按照随机数字表法将其分为对照组(n=39)和试验组(n=39)。对照组采用更昔洛韦治疗,试验组在对照组基础上联合重组人干扰素α-1b治疗。采用回顾性分析的方法,比较两组的临床效果和免疫功能指标。结果试验组的临床总有效率为94.87%,显著高于对照组的76.92%,差异有统计学意义(P<0.05);试验组的异型淋巴细胞下降率为89.74%,显著高于对照组的71.79%,差异有统计学意义(P<0.05)。试验组治疗前3 d的T淋巴细胞亚群CD3^+、CD4^+、CD8^+与对照组相比,差异无统计学意义(P>0.05);治疗10 d后两组上述指标均较治疗前改善,且试验组CD3^+、CD8^+水平低于对照组,CD4^+水平高于对照组,差异有统计学意义(P<0.05)。结论更昔洛韦联合重组人干扰素α-1b治疗IM患儿的临床效果显著,抗病毒效果理想,有助于改善患儿免疫功能。Objective To explore the clinical efficacy of recombinant human interferon alpha-1b combined with ganciclovir in the treatment of infectious mononucleosis in children and its influence on the immunity of children,to provide references for clinicians to choose rational drug regimens.Methods A total of 78 cases with children infectious mononucleosis admitted to Lingyuan Central Hospital from March 2017 to February 2018 were selected as the study subjects.They were divided into two groups according to the random number grouping method:control group and experimental group(39 cases in each group).The control group was treated with ganciclovir;the experimental group was treated with recombinant human interferon alpha-1b combined with ganciclovir.The clinical efficacy and immune indexes were compared between the two groups by a retrospective analysis.Results The total clinical effective rate of the experimental group was 94.87%,significantly higher than that of the control group(76.92%)(P<0.05);the negative rate of EBV-DNA in the experimental group was 89.74%,significantly higher than that of the control group(71.79%)(P<0.05);there was no significant difference in CD3^+,CD4^+,CD8^+of T lymphocyte subsets between the experimental group and the control group 3 days before treatment(P>0.05),and the above indexes were improved in both groups 10 days after treatment,the levels of CD3^+and CD8^+in group experimental were lower than those in control group,and CD4^+was higher than those in control group(P<0.05).Conclusion Ganciclovir combined with recombinant human interferon alpha-1b is effective in the treatment of infectious mononucleosis in children.It has ideal antiviral effect and can improve the immune function of children.

关 键 词：传染性单核细胞增多症 儿童 更昔洛韦 重组人干扰素Α-1B 临床疗效 免疫功能 

分 类 号：R725.1[医药卫生—儿科]