多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的临床效果  

Clinical Effect of Polyene Phosphatidylcholine on Intrahepatic Cholestasis of Pregnancy

作　　者：姜翠玲 JIANG Cuiling(Department of Obstetrics and Gynecology,Xuzhou Heping Maternity Hospital,Xuzhou 221000,China)

机构地区：[1]徐州和平妇产医院妇产科,江苏徐州221000

出　　处：《中国医药指南》2020年第36期13-15,共3页Guide of China Medicine

摘　　要：目的分析多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的临床效果。方法本次试验研究的对象为2016年8月至2019年8月在我院接受妊娠期肝内胆汁淤积症治疗的患者98例,根据随机平均分组原则将患者分为人数相等的研究组与对照组,每组各有患者49例。对照组患者采用腺苷蛋氨酸联合熊去氧胆酸治疗,研究组患者在对照组患者的基础上加用多烯磷脂酰胆碱。结果治疗后总胆汁酸、总胆红素、天冬氨酸转氨酶、血清丙氨酸转氨酶研究组均低于对照组,而瘙痒评分研究组少于对照组,瘙痒消失时间、黄疸消失时间研究组更短,妊娠结局的比较上研究组优于对照组(P<0.05);两组患者治疗前瘙痒评分无明显差异(P>0.05)。结论在为妊娠期肝内胆汁淤积患者实施治疗的过程中,在腺苷蛋氨酸联合熊去氧胆酸治疗基础上加用多烯磷脂酰胆碱可改善患者总胆汁酸、总胆红素、天冬氨酸转氨酶、血清丙氨酸转氨酶及瘙痒评分,缩短瘙痒、黄疸消失时间,改善患者的妊娠结局。Objective To analyze the clinical effect of polyene phosphatidylcholine in the treatment of intrahepatic cholestasis during pregnancy.Methods The subjects of this trial were 98 patients who were treated for intrahepatic cholestasis of pregnancy in our hospital from August 2016 to August 2019.According to the principle of random average grouping,the patients were divided into an equal number of study and control groups.There are 49 patients in each group.Patients in the control group were treated with adenosylmethionine combined with ursodeoxycholic acid,and patients in the study group were treated with polyene phosphatidylcholine on the basis of the control group.Results After treatment,the total bile acid,total bilirubin,aspartate aminotransferase,and serum alanine aminotransferase in the study group were lower than those in the control group,while the pruritus score in the study group was lower than in the control group.The disappearance time of pruritus and jaundice was shorter in the study group.The study group was better than the control group in comparison of pregnancy outcomes(P<0.05);there was no significant difference in pruritus scores between the two groups before treatment(P>0.05).Conclusion In the process of treatment for patients with intrahepatic cholestasis of pregnancy,the addition of polyene phosphatidylcholine to the treatment of adenosylmethionine combined with ursodeoxycholic acid can improve the total bile acid,total bilirubin,and aspartame.Amino acid aminotransferase,serum alanine aminotransferase and pruritus score can shorten the disappearance time of pruritus and jaundice,and improve the patient's pregnancy outcome.

关 键 词：妊娠期肝内胆汁淤积症 多烯磷脂酰胆碱 总胆汁酸 瘙痒评分 

分 类 号：R714.255[医药卫生—妇产科学]