Expanding beyond canonical metabolism:Interfacing alternative elements,synthetic biology,and metabolic engineering  

作　　者：Kevin B.Reed Hal S.Alper 

机构地区：[1]McKetta Department of Chemical Engineering,The University of Texas at Austin,200E Dean Keeton St.Stop C0400,Austin,TX 78712,USA [2]Institute for Cellular and Molecular Biology,The University of Texas at Austin,2500 Speedway Avenue,Austin,TX 78712,USA

出　　处：《Synthetic and Systems Biotechnology》2018年第1期20-33,共14页合成和系统生物技术（英文）

基　　金：We acknowledge support from The Camille and Henry Dreyfus Teacher Scholar Program,The Welch Foundation under Grant F-1753,and the Air Force Office of Scientific Research under Award No.FA9550-14-1-0089.

摘　　要：Metabolic engineering offers an exquisite capacity to produce new molecules in a renewable manner.However,most industrial applications have focused on only a small subset of elements from the periodic table,centered around carbon biochemistry.This review aims to illustrate the expanse of chemical elements that can currently(and potentially)be integrated into useful products using cellular systems.Specifically,we describe recent advances in expanding the cellular scope to include the halogens,selenium and the metalloids,and a variety of metal incorporations.These examples range from small molecules,heteroatom-linked uncommon elements,and natural products to biomining and nanotechnology applications.Collectively,this review covers the promise of an expanded range of elemental incorporations and the future impacts it may have on biotechnology.

关 键 词：Metabolic engineering Synthetic biology Unnatural metabolism HALOGENATION Cellular factories Non-canonical elements 

分 类 号：F42[经济管理—产业经济]