Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury(TBI)in rats  

作　　者：Guang Cheng Zhiwei Yue Liwen Wang Yutaka Miyauchi Michiko Suzawa Shiming Li Chi-Tang Ho Hui Zhao Naiyao Chen 

机构地区：[1]Department of Hematology and Tangshan Key Laboratory,Translational Medical Center,North China University of Science and Technology,Tangshan,Hebei 063000,China [2]Tianjin Key Laboratory of Food and Biotechnology,School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China [3]Miyauchi Citrus Research Center,Takasaki,Gunma,Japan [4]Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources,Huanggang Normal University,Huanggang,Hubei 438000,China [5]Department of Food Science,Rutgers,The State University of New Jersey,New Brunswick,New Jersey 08901,United States

出　　处：《Food Science and Human Wellness》2020年第3期229-236,共8页食品科学与人类健康（英文）

摘　　要：Traumatic brain injury(TBI)is closely related to neuro-inflammatory response and causes a complex pathological process and serious consequence.In this study,we explored whether the formatted citrus peel extract gold lotion(GL)could have a therapeutic effect on rats suffered TBI.TBI rat model was prepared by the electric Cortical Contusion Impactor(eCCI)device.Prevention against TBI by GL was assessed by the behavioral,organizational of rats and the molecular markers in the brain injury area.The results showed that GL could reduce nerve damage and neurological dysfunction.The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP,OX-42,TNF-α,COX-2,NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury area.These findings revealed that GL could be a promising preparation for TBI prevention.

关 键 词：Citrus peel COGNITIVE Traumatic brain injury Inflammation Gold lotion 

分 类 号：TQ460.1[化学工程—制药化工]