α-Glucosidase inhibitor produced by an endophytic fungus, Xylariaceae sp. QGS 01 from Quercus gilva Blume  

作　　者：Anastasia Wheni Indrianingsih Sanro Tachibana 

机构地区：[1]Research Unit for Natural Products Technology,Indonesian Institute of Sciences,Gading,Playen,Gunungkidul,Yogyakarta,55581,Indonesia [2]Department of Applied Biosciences,Faculty of Agriculture,Ehime University,3-5-7 Tarumi Matsuyama,Ehime 790-8566,Japan

出　　处：《Food Science and Human Wellness》2017年第2期88-95,共8页食品科学与人类健康（英文）

摘　　要：Xylariaceae sp.QGS 01,an endophytic fungus isolated from the stem of Quercus gilva Blume showed high-glucosidase inhibitory activity.α-Glucosidase inhibitor have the role as one of carbohydrate-hydrolyzing enzymes to postpone absorption of glucose in the digestive organs.The α-glucosidase inhibitor constituents were isolated from the ethyl acetate extract of the mycellium of endophytic fungi Xylariaceae sp.QGS 01 using a bioassay-guided fractionation technique.Further separation and purification of the active fraction led to the isolation of constituents with strong inhibitory activities against-glucosidase:8-hydroxy-6,7-dimethoxy-3-methylisocoumarine(1)with inhibitory concentration(IC50)values against-glucosidase from Saccharomyces cerevisiae of 41.75μg/mL,while quercetin as the standard had an IC50 value of 4.80g/mL.The results of the present study showed that the endophytic fungus Xylariaceae sp.QGS 01 is potentially a rich source of antidiabetic medicine.

关 键 词：Endophytic fungi Quercus qilva Blume α-Glucosidase inhibitory activity Xylariaceae sp. Isocoumarine derivative 

分 类 号：TQ460.1[化学工程—制药化工]