血清胆红素、血尿酸、C-反应蛋白水平与慢性阻塞性肺疾病急性加重及其综合评估的相关性研究  

The correlation of serum bilirubin,serum uric acid and c-reactive protein levels with acute exacerbation of COPD and comprehensive assessment of COPD

作　　者：陈环宇 辛雯艳 许西琳[2] 高岩[2] 刘冬[2] CHEN Huan-yu;XIN Wen-yan;XU Xi-lin(Medicine Collage of Shihezi University,Shihezi 829000,China;Department of Respiratory Medicine,the first affiliated hospital of Shihezi University,shihezi 832000,China)

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学第一附属医院呼吸内科,新疆石河子832000

出　　处：《吉林医学》2021年第2期273-276,共4页Jilin Medical Journal

基　　金：科技支疆计划项目[项目编号:2014AB030]。

摘　　要：目的:探讨血清胆红素(total bilirubin,TBIL)、血尿酸(uric acid,UA)、C-反应蛋白(C-reactive protein,CRP)与慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)及慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)综合评估相关性研究。方法:选择2017年10月~2019年6月石河子大学第一附属医院115例AECOPD住院患者,并收集其经过7~14 d治疗后进入COPD期的病例资料,用自身配对样本t检验描述AECOPD组、COPD组TBIL、直接胆红素(direct bilirubin,DBIL)、间接胆红素(indirect bilirubin,IBIL)、UA、CRP值的水平变化,用呼吸困难指数mMRC、COPD评估测试CAT、急性加重史将COPD患者分为A、B、C、D组,同期用GOLD分级将COPD患者分为Ⅰ~Ⅳ级,采用单因素方差分析比较每组TBIL、UA、CRP值的水平变化。结果:自身配对样本t检验显示,AECOPD组TBIL、UA、CRP值均高于COPD组,差异有统计学意义(P<0.05)。方差分析显示,A~D组TILB、UA基本呈逐渐降低趋势,CRP变化趋势不明显,仅B组、D组差异有统计学意义(P<0.05);Ⅰ~Ⅳ级别与TILB、UA、CRP水平无明显相关。结论:TIBL、UA、CRP三者有良好的一致性预测AECOPD的发生,并与COPD综合评估相关。Objective Serum bilirubin(TBIL),blood uric acid(UA)and c-reactive protein(CRP)with acute exacerbation of chronic obstructive pulmonary diseases(AECOPD)and chronic obstructive pulmonary diseases(COPD)comprehensive assessment of correlation study.Method Collected in October 2017 to June 2019 shihezi university first affiliated hospital,115 cases of hospitalized patients with AECOPD,and after a period of 7 to 14 days after treatment in COPD cases data,with its paired sample test description AECOPD group,COPD group of TBIL,DBIL(direct bilirubin),IBIL(indirect bilirubin)the level of UA and CRP value change.COPD patients were divided into groups A,B,C and D by mMRC dyspnea index,CAT COPD assessment test and history of acute exacerbation.COPD patients were classified intoⅠ-Ⅳgrade by GOLD grade at the same time.Results The TBIL,UA and CRP values in AECOPD group were higher than those in COPD group(all P<0.05).Variance analysis showed that TILB and UA in the A-D group showed A gradually decreasing trend,while CRP showed no obvious trend,with only differences in the B and D groups.GradeⅠ-Ⅳshowed no significant correlation with TILB,UA and CRP levels.Conclusion TIBL,UA and CRP have good consistency in predicting the occurrence of AECOPD and are related to the comprehensive evaluation of COPD.

关 键 词：慢性阻塞性肺疾病 急性加重 综合评估 血清胆红素 血尿酸 C-反应蛋白 

分 类 号：R563.9[医药卫生—呼吸系统]