军团菌感染致肺外表现及调控机制研究进展  

Advances in research on the extrapulmonary manifestations and its regulatory mechanism of Legionella infection

作　　者：王佳鑫 于墨池 陈愉[1] WANG Jiaxin;YU Mochi;CHEN Yu(Department of Respiratory and Critical Care Medicine,Shengjing Hospital of China Medical University,Shenyang,Liaoning 110000,P.R.China)

机构地区：[1]中国医科大学附属盛京医院呼吸与危重症医学科,沈阳110000

出　　处：《华西医学》2021年第1期8-13,共6页West China Medical Journal

基　　金：国家自然科学基金(81170009);科技部重点研发计划资助项目(2017YFC1309702)。

摘　　要：军团菌感染首次暴发于1976年美国费城退伍军人大会,是非典型肺炎的病原体之一,感染时可累及全身多系统病变,其肺外表现包括以腹泻和肝功能异常为主的消化系统症状,以头痛、定向力障碍、精神状态改变为主的神经系统症状,以横纹肌溶解为主的肌损伤,以血尿、蛋白尿、急性肾损伤为主的泌尿系统症状和以低钠血症、低磷血症为主的离子紊乱等。该文将结合国内外文献对军团菌感染致肺外表现及其调控机制作一综述。Legionella,one of the causative pathogens of atypical pneumonia,firstly outbroked during the period of American Legion’s convention in 1976,Philadelphia.Legionella infection can accompany multisystem involvement.In addition to pulmonary lesions,it also accompanies extrapulmonary manifestations,including gastrointestinal symptoms(primarily diarrhea and hepatic dysfunction),neurological symptoms(primarily headache,disorientation and confusion of consciousness),urinary symptoms(primarily hematuria,proteinuria and acute kidney injury),rhabdomyolysis,as well as electrolyte disorder mainly characterized by hyponatremia and hypophosphatemia.This article reviews the extrapulmonary manifestations and its regulatory mechanism of Legionella infection.

关 键 词：军团菌 肺外表现 调控机制 

分 类 号：R563.1[医药卫生—呼吸系统]