夜间光暴露与人体不良健康结局关联的研究进展  

Research progress on the relationship between light at night and adverse health outcomes in humans

作　　者：徐玉祥 孙莹[1,2,3] XU Yu-xiang;SUN Ying(School of public health,Anhui Medical University,Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]出生人口健康教育部重点实验室,安徽合肥230032 [3]人口健康与优生安徽省重点实验室,安徽合肥230032

出　　处：《现代预防医学》2021年第2期222-225,共4页Modern Preventive Medicine

基　　金：国家自然科学基金(81872638);安徽省自然科学基金杰青项目(1908085J26)。

摘　　要：目的综述夜间光暴露与睡眠节律紊乱、肥胖、乳腺癌和情绪障碍等多种不良健康结局关联的最新研究,阐述其可能的关联机制。方法查阅PubMed及中国知网中近100篇与夜间光暴露(light at night,LAN)的危害作用相关文献,经整合筛选后,最终参考了与主题相关的33篇文献。结果长时间的夜间光暴露能扰乱由内源性生物钟控制的生理过程,并潜在地导致多种人体不良健康结局。结论LAN与多种人体不良健康结局相关,未来需更多的干预和纵向研究明确其关联机制,阐明减少LAN的干预措施是否会对人体健康产生积极影响。Objective To review the latest research on the association between night light exposure and various adverse health outcomes such as sleep rhythm disturbance,obesity,breast cancer and mood disorders,and to explain the possible mechanism.Methods Nearly 100 research papers related to the harmful effects of light at night(LAN)were retrieved from PubMed and CNKI,and 33 papers were included after integration and evaluation.Results Prolonged night light exposure could disrupt the physiological processes regulated by the endogenous circadian clock,thus potentially leading to varied adverse health outcomes in humans.Conclusion LAN is associated with a variety of adverse human health outcomes.More interventions and longitudinal studies are needed to elucidate the correlation mechanism and clarify whether the intervention measures to reduce LAN will have a positive impact on human health.

关 键 词：夜间光暴露 不良健康结局 睡眠节律紊乱 肥胖 癌症 乳腺癌 

分 类 号：R122[医药卫生—环境卫生学]